Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor
JG DeKeyser, EM Laurenzana… - Toxicological …, 2011 - academic.oup.com
Phthalates and other endocrine-disruptive chemicals are manufactured in large quantities
for use as plasticizers and other commercial applications, resulting in ubiquitous human …
for use as plasticizers and other commercial applications, resulting in ubiquitous human …
Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2
JG DeKeyser, MC Stagliano, SS Auerbach… - Molecular …, 2009 - ASPET
… In separate experiments (DeKeyser et al., manuscript in preparation), we demonstrated that
no … assistance of Denise Weyant and thank Matthew DeKeyser for graphical assistance. …
no … assistance of Denise Weyant and thank Matthew DeKeyser for graphical assistance. …
Considerations from the innovation and quality induction working group in response to drug-drug interaction guidances from regulatory agencies: focus on CYP3A4 …
…, M Mohutsky, HJ Einolf, L Chen, JG Dekeyser… - Drug Metabolism and …, 2018 - ASPET
The Innovation and Quality Induction Working Group presents an assessment of best practice
for data interpretation of in vitro induction, specifically, response thresholds, variability, …
for data interpretation of in vitro induction, specifically, response thresholds, variability, …
Considerations from the IQ induction working group in response to drug-drug interaction guidance from regulatory agencies: focus on downregulation, CYP2C …
…, D Ramsden, J Palamanda, JG Dekeyser… - Drug Metabolism and …, 2017 - ASPET
The European Medicines Agency (EMA), the Pharmaceutical and Medical Devices Agency (PMDA),
and the Food and Drug Administration (FDA) have issued guidelines for the conduct …
and the Food and Drug Administration (FDA) have issued guidelines for the conduct …
CAR2 displays unique ligand binding and RXRα heterodimerization characteristics
SS Auerbach, JG DeKeyser, MA Stoner… - Drug metabolism and …, 2007 - ASPET
The constitutive androstane receptor (CAR; NR1I3) regulates the expression of genes involved
in xenobiotic metabolism. Alternative splicing of the human CAR gene yields an array of …
in xenobiotic metabolism. Alternative splicing of the human CAR gene yields an array of …
Bioassay‐directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision‐induced dissociation
MC Stagliano, JG DeKeyser… - Rapid …, 2010 - Wiley Online Library
We report a synergistic method using bioassay‐directed liquid chromatography fractionation
and time‐of‐flight mass spectrometry to guide and accelerate bioactive compound discovery…
and time‐of‐flight mass spectrometry to guide and accelerate bioactive compound discovery…
Studies on titin PEVK peptides and their interaction
Y Duan, JG DeKeyser, S Damodaran… - Archives of biochemistry …, 2006 - Elsevier
Experiments were conducted on several synthetic and expressed peptides from the PEVK
region of titin, the giant muscle protein. Different secondary structure prediction methods …
region of titin, the giant muscle protein. Different secondary structure prediction methods …
Species differences of drug‐metabolizing enzymes
JG DeKeyser, M Shou - Encyclopedia of drug metabolism and …, 2011 - Wiley Online Library
The prediction of human pharmacokinetics, efficacy, and toxicity from preclinical data
remains an important goal in the drug discovery and development process to minimize risk to …
remains an important goal in the drug discovery and development process to minimize risk to …
Enzyme Induction Studies in Drug Discovery and Development
JG Dekeyser, JL Wahlstrom - Handbook of Drug Metabolism, Third …, 2019 - taylorfrancis.com
Changes in the expression of absorption, distribution, metabolism and excretion (ADME)
genes can impact the pharmacokinetics of many small molecule drugs. This chapter aims to …
genes can impact the pharmacokinetics of many small molecule drugs. This chapter aims to …
[PDF][PDF] CAR2 displays unique ligand binding and RXRα heterodimerization characteristics
JG Dekeyser, SS Auerbach, MA Stoner, CJ Omiecinski - 2007 - Citeseer
The constitutive androstane receptor (CAR, NR1I3) regulates the expression of genes involved
in all phases of xenobiotic metabolism. Alternative splicing of the human CAR transcript …
in all phases of xenobiotic metabolism. Alternative splicing of the human CAR transcript …