Introduction: Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related
disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not …

Genotype is increasingly recognized as an important factor influencing the likelihood for drug
effectiveness or risk for adverse events. Genetic information is now included in US Food …

Identification of novel variants that contribute to response heterogeneity supports future studies
of single nucleotide polymorphism discovery and include gene expression and genome-…

Background The response to treatment for asthma is characterized by wide interindividual
variability, with a significant number of patients who have no response. We hypothesized that …

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic
and environmental factors 1 , 2 . Through a genome-wide association study and a replication …

Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and
prevention of many conditions, including gastroesophageal reflux disease, gastric and duodenal …

Rationale: Interpatient variability in montelukast response may be related to variation in
leukotriene pathway candidate genes. Objective: To determine associations between …

Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge
on the subject. The National Institute on Aging convened this workshop to identify what is …

Background Phenotypic presentations in young children with asthma are varied and might
contribute to differential responses to asthma controller medications. Methods The …

Objective To determine whether genetic polymorphisms of the β 2 ‐adrenergic receptor gene
affect the relationship between albuterol (INN, salbutamol) plasma concentrations and the …