The measurement of dimethylamine, trimethylamine, and trimethylamine N-oxide using capillary gas chromatography-mass spectrometry

JJ Vrbanac, SH Zeisel - Analytical biochemistry, 1990 - Elsevier
We have developed a method for measuring dimethylamine (DMA), trimethylamine (TMA),
and trimethylamine N-oxide (TMAO) in biological samples using gas chromatography with …

Prostacyclin and Thromboxane A2 Formation Is Increased in Human Sepsis Syndrome: Effects of Cyclooxygenase Inhibition

…, PE Wright, FL Watts, JJ Vrbanac - American Review of …, 1991 - atsjournals.org
Arachidonic acid metabolites, especially thromboxane-A 2 and prostacyclin, have been
shown to be increased in experimental models of sepsis and the adult respiratory distress …

Automated qualitative and quantitative metabolic profiling analysis of urinary steroids by a gas chromatography-mass spectrometry-data system

JJ Vrbanac, WE Braselton Jr, JF Holland… - … of Chromatography A, 1982 - Elsevier
A computer system (MSSMET), using methylene unit retention indices for an off-line reverse
library search analysis of selected ion chromatograms from gas chromatography-mass …

Extraction of thromboxane B2 from urine using an immobilized antibody column for subsequent analysis by gas chromatography-mass spectrometry

…, DE Mais, PV Halushka, RH Baker, IA Blair, JJ Vrbanac - Prostaglandins, 1987 - Elsevier
This paper describes an antibody affinity (immunoaffinity) column which, in one step, extracts
and sufficiently purifies urinary thromboxane B 2 (TXB 2 ) for quantitative analysis by high …

Utility of the parent‐neutral loss scan screening technique: Partial characterization of urinary metabolites of U‐78875 in monkey urine

JJ Vrbanac, IA O'leary… - Biological mass …, 1992 - Wiley Online Library
Metabolites of an antianxiety‐sedative drug candidate (U‐78875; 3‐(5‐cyclopropyl‐1,2,4‐oxadiazol‐3‐yl)‐5‐(1‐methylethyl)‐imidazo
[1,5‐α] quinoxalin‐4(5H)‐one (I)) present in the …

Identification of the metabolites of the HIV-1 reverse transcriptase inhibitor delavirdine in monkeys

…, PE Fagerness, PE Sanders, JJ Vrbanac - Drug metabolism and …, 1997 - ASPET
Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside HIV-1 reverse
transcriptase inhibitor currently under development for the treatment of AIDS. The metabolism of …

Quantitative analysis of 6-keto-prostaglandin F1α using immunoaffinity purification and gas chromatography—mass spectrometry

JJ Vrbanac, TD Eller, DR Knapp - Journal of Chromatography B …, 1988 - Elsevier
This paper describes an immunoaffinity purification technique for 6-keto-prostaglandin F 1α (6KPGF
1α ) prior to quantitative analysis by high-resolution gas chromatography—negative-…

Automated metabolic profiling analysis of urinary steroids by a gas chromatography mass spectrometry data system

JJ Vrbanac, CC Sweeley… - Biomedical Mass …, 1983 - Wiley Online Library
A computer system (MSSMET), using methylene unit retention indices for an off‐line reverse
library search analysis of selected ion chromatograms from gas‐liquid chromatographic …

High‐resolution isotope‐dilution mass spectrometry using metabolism of isotope‐labeled compounds: Application to drug metabolites

JJ Vrbanac, A Hilgers, T Dubnicka… - Rapid …, 2012 - Wiley Online Library
RATIONALE Herein we describe a generic quantitative method using high‐resolution,
isotope‐dilution (HRID) metabolism of isotope‐labeled compounds and apply it to the analysis of …

Comparison of 2, 5-dimethoxy-4-methylamphetamine (DOM) and d-amphetamine for in vivo efflux of catecholamines from rat brain

JJ Vrbanac, HA Tilson, KE Moore, RH Rech - … Biochemistry and Behavior, 1975 - Elsevier
The neurochemical effects of DOM and d-amphetamine were compared under several
conditions in unanesthetized rats implanted with chronic-indwelling push-pull cannulae in a …