Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus

JL Treadway, P Mendys, DJ Hoover - Expert opinion on …, 2001 - Taylor & Francis
Type 2 diabetes mellitus is a severe disease with large economic consequences, which is
significantly under-diagnosed and incompletely treated in the general population. Control of …

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

…, EJ Barrett, JL Treadway - Proceedings of the …, 1998 - National Acad Sciences
An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and
characterized in vitro and in vivo. This substance, [R-(R*,S*)]-5-chloro-N-[3-(dimethylamino)-2-…

Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([RR*, S*]-5-chloro-N-[2-hydroxy-3 …

SW Suh, JP Bergher, CM Anderson, JL Treadway… - … of Pharmacology and …, 2007 - ASPET
Glycogen in the brain is localized almost exclusively to astrocytes. The physiological function
of this energy store has been difficult to establish because of the difficulty in manipulating …

[PDF][PDF] Human liver glycogen phosphorylase inhibitors bind at a new allosteric site

…, RK McPherson, TV Olson, JL Treadway… - Chemistry & biology, 2000 - cell.com
Background: Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate
for glycolysis. Maintaining control of blood glucose levels is critical in minimizing …

Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes …

…, KM Ward, AW Schmidt, WS Lebel, JL Treadway… - Diabetes, 2005 - Am Diabetes Assoc
Treatment with the atypical antipsychotics olanzapine and clozapine has been associated
with an increased risk for deterioration of glucose homeostasis, leading to hyperglycemia, …

In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET

…, RA Calle, RE Carson, JL Treadway… - Journal of nuclear …, 2012 - Soc Nuclear Med
The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate …

…, J Litchfield, R Aiello, JL Treadway… - Journal of medicinal …, 2012 - ACS Publications
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric
activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. …

The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis

AM Betts, TH Clark, J Yang, JL Treadway, M Li… - … of Pharmacology and …, 2010 - ASPET
PF-04840082 is a humanized prototype anti-Dickkopf-1 (Dkk-1) immunoglobulin isotype G
2 (IgG 2 ) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, …

Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase

…, PE Genereux, EM Gibbs, JL Treadway - Journal of medicinal …, 1998 - ACS Publications
Treadway. 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase:
synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorganic & Medicinal …

[HTML][HTML] Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for …

…, JD Baker, M Kuhn, O Cabrera, JL Treadway - BMC genomics, 2011 - Springer
Background Glucagon is an important hormone in the regulation of glucose homeostasis,
particularly in the maintenance of euglycemia and prevention of hypoglycemia. In type 2 …