[HTML][HTML] CNS Delivery Via Adsorptive Transcytosis
F Hervé, N Ghinea, JM Scherrmann - The AAPS journal, 2008 - Springer
… Nervous System Delivery of Therapeutic Molecules Guest Editors: Jean-Michel Scherrmann
… Data are mean ± SD (n = 5 rats for each antibody; JM Scherrmann, unpublished results) …
… Data are mean ± SD (n = 5 rats for each antibody; JM Scherrmann, unpublished results) …
Colchicine today
E Niel, JM Scherrmann - Joint bone spine, 2006 - Elsevier
Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory
diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in …
diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in …
Drug delivery to brain via the blood–brain barrier
JM Scherrmann - Vascular pharmacology, 2002 - Elsevier
1. Many neurodegenerative diseases, cancer and infections of the brain become more
prevalent as populations become older. Despite major advances in neuroscience, the blood–…
prevalent as populations become older. Despite major advances in neuroscience, the blood–…
New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy
…, JM Lefauconnier, M Kaczorek, JM Scherrmann… - Molecular …, 2000 - ASPET
Many therapeutic drugs are excluded from entering the brain, due to their lack of transport
through the blood-brain barrier (BBB). To overcome this problem, we have developed a novel …
through the blood-brain barrier (BBB). To overcome this problem, we have developed a novel …
Puromycin‐based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood–brain barrier‐specific properties
…, P Couvreur, JM Scherrmann… - Journal of …, 2005 - Wiley Online Library
One of the main difficulties with primary rat brain endothelial cell (RBEC) cultures is obtaining
pure cultures. The variation in purity limits the achievement of in vitro models of the rat …
pure cultures. The variation in purity limits the achievement of in vitro models of the rat …
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
…, PO Couraud, T Terasaki, JM Scherrmann - Molecular …, 2011 - ACS Publications
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC)
and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 …
and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 …
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier
…, PO Couraud, JM Scherrmann… - Journal of …, 2008 - Wiley Online Library
We have established the expression patterns of the genes encoding ATP‐binding cassette (ABC)
transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (…
transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (…
Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier
…, C Mercier, F Bourasset, F Roux, JM Scherrmann - Cancer research, 2004 - AACR
The breast cancer resistance protein (BCRP/ABCG2) is, like P-glycoprotein (P-gp), a member
of the ABC family of drug transporters. These proteins actively transport various anticancer …
of the ABC family of drug transporters. These proteins actively transport various anticancer …
[HTML][HTML] Treatment of severe colchicine overdose with colchicine-specific Fab fragments
…, JM Rouzioux, JM Scherrmann - … England Journal of …, 1995 - Mass Medical Soc
The use of colchicine is limited by its toxicity, 1 and colchicine overdose is associated with a
high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose …
high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose …
Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line …
…, F Glacial, X Decleves, JM Scherrmann… - Molecular …, 2013 - ACS Publications
Human cerebral microvascular endothelial cell line hCMEC/D3 is an established model of
the human blood–brain barrier (BBB). The purpose of the present study was to determine, by …
the human blood–brain barrier (BBB). The purpose of the present study was to determine, by …