Since 1978 a number of reports have indicated a possible association between sodium
valproate therapy and the occurrence of hepatitis. In this review we have analysed, with …

Background & Aims: The maintenance of the intestinal mucosal barrier may be energy
dependent. Tacrolimus is a potent immunosuppressive drug that decreases mitochondrial …

… Davenport M, Gonde C, Narayanaswamy B, Mieli-Vergani G, Tredger JM. Soluble
adhesion molecule profiling in preoperative infants with biliary atresia. J Pediatr Surg 2005;40:1464-…

The value of coagulation factor V and VIII/V levels as prognostic indicators was assessed in
27 patients with fulminant hepatic failure and compared with other predictive indices. …

… 3 Read RB, Tredger JM & Williams R. Analysis of factors responsible for continuing mortality
… 4 Bray GP, Mowat C, Muir DF, Tredger JM & Williams R. The effect of chronic alcohol intake …

The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied
in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 …

Predose plasma mycophenolic acid (MPA) concentrations measured with a semi‐automated
enzyme‐multiplied immunoassay were related to adverse events (eg, rejection, leukopenia…

Precision-cut human liver slices obtained from 11 donors were cultured for 72 h in a defined
medium (serum free Williams' medium E) supplemented with 0.1 μM insulin and 0.1 μM …

The pediatric transplant community stands at a time of unprecedented choice of immunosuppressive
agents – and with a legacy of morbidity from those agents used in the previous two …

Background/Aims: Toxicity and efficacy of azathioprine is governed partly by the activity of
thiopurine methyltransferase (TPMT). Azathioprine has been used for many years, with …