In humans, the antimalarial drug chloroquine (CQ) is metabolized into one major metabolite,
N-desethylchloroquine (DCQ). Using human liver microsomes (HLM) and recombinant …

Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters modulate
the transport and metabolism of both endogenous and exogenous substrates and could play …

The molecular mechanisms by which cyclosporine induces chronic nephrotoxicity remain
poorly understood. A previous transcriptomic study suggested that cyclosporine might induce …

Background/Aims: We have identified several clones specifically expressed during malignant
cell proliferation by screening a complementary DNA library constructed from a human …

The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is
rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the …

Previous studies of propofol (2,6-diisopropylphenol) pharmacology have shown that this
widely used anaesthetic drug is extensively cleared from the body by conjugation of the parent …

Caffeine biotransformation and four monooxygenase activities involving cytochrome P-450IA2,
namely ethoxy- and methoxyresorufin O-dealkylases, phenacetin O-deethylase, and …

Hepatocytes from adult and newborn humans were put into primary culture and exposed to
phenobarbital, 3‐methylcholanthrene, or rifampicin, three well‐known inducers of …

The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of
quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome …

The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the
biotransformation of clomipramine in vitro. A high-performance liquid chromatography method was …