… Kehrer … and Kehrer, JP, Production … Kehrer, JP, Concepts related to the study of reactive
oxygen and cardiac reperfusion injury. Free Rud. Res. …

The concept that the highly reactive hydroxyl radical (HO ) could be generated from an
interaction between superoxide (O 2 − ) and hydrogen peroxide (H 2 O 2 ) was proposed (with …

Acrolein is a highly electrophilic α,β-unsaturated aldehyde to which humans are exposed in
a variety of environmental situations, particularly as a component of smoke. In addition, as a …

Cyclophosphamide, an orally active alkylating agent, is widely used to treat a variety of malignant
and nonmalignant disorders. Although it has some tumour selectivity, it also possesses …

… In 1993, one of us (JPK) wrote a comprehensive review article for Critical Reviews in
Toxicology (Kehrer Citation1993) covering the basics of free radical biochemistry, as well as our …

Energy has been proposed to play a role in the ability of cells and tissues to defend against
oxidative stress, even though the ultimate antioxidant capacity of a tissue is determined by …

Due to the dominating roles that caspases play in the apoptotic cascade, their activities appear
to be a primary factor in the death pathway (apoptosis versus oncosis/necrosis) decision. …

… JP Kehrer, unpublished data). Although Trx activity was virtually eliminated in A549 cells
immediately after treatment with acrolein, western blot analyses of Trx-1 protein levels revealed …

… Tong and JP Kehrer, unpublished work), and all are toxic to tumour cells, but relatively
non-toxic to normal cells ([25], and Z. Tong and JP Kehrer, unpublished work). This raises the …

… The 8-S-HETEenhanced expression of another PPARα responsive gene, acylCoA oxidase,
was only minimally affected in keratinocytes by MK886 (JP Kehrer, P. Thuillier and SM …