Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
J Seubert, B Yang, JA Bradbury, J Graves… - Circulation …, 2004 - Am Heart Assoc
Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic
acids (EETs); however, the functional role of this P450 and its eicosanoid products in the …
acids (EETs); however, the functional role of this P450 and its eicosanoid products in the …
Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation
JW Card, MA Carey, JA Bradbury… - The Journal of …, 2006 - journals.aai.org
The roles of gender and sex hormones in lung function and disease are complex and not
completely understood. The present study examined the influence of gender on lung function …
completely understood. The present study examined the influence of gender on lung function …
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
…, CJ Sinal, J Graves, LM DeGraff, JA Bradbury… - Circulation …, 2006 - Am Heart Assoc
Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids
(EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide …
(EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide …
Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues
…, SJ Coulter, D Dai, JF Foley, JA Bradbury… - Drug Metabolism and …, 2007 - ASPET
The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic
acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular …
acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular …
Polymorphisms in human soluble epoxide hydrolase
…, JE Maxwell, BD Hammock, JA Bradbury… - Molecular …, 2003 - ASPET
Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding
vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous …
vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous …
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids
Vascular smooth muscle cell (SMC) migration and proliferation contribute to neointimal
hyperplasia and restenosis after vascular injury. The epoxyeicosatrienoic acids (EETs), which …
hyperplasia and restenosis after vascular injury. The epoxyeicosatrienoic acids (EETs), which …
Cloning of CYP2J2 gene and identification of functional polymorphisms
…, J Ma, S Srettabunjong, J Graves, JA Bradbury… - Molecular …, 2002 - ASPET
CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic
acid to eicosanoids that possess potent anti-inflammatory, vasodilatory, and fibrinolytic …
acid to eicosanoids that possess potent anti-inflammatory, vasodilatory, and fibrinolytic …
[HTML][HTML] Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice
…, ML Edin, J Foley, LM DeGraff, JA Bradbury… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium
transport and blood pressure. Although endothelial CYP-derived EETs are potent vasodilators…
transport and blood pressure. Although endothelial CYP-derived EETs are potent vasodilators…
[HTML][HTML] Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
…, LM DeGraff, FB Lih, J Foley, JA Bradbury… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory
effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis …
effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis …
[HTML][HTML] Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
ML Edin, ZJ Wang, JA Bradbury, JP Graves… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Cytochrome P450 (CYP) epoxygenases CYP2C8 and CYP2J2 generate epoxyeicosatrienoic
acids (EETs) from arachidonic acid. Mice with expression of CYP2J2 in cardiomyocytes (…
acids (EETs) from arachidonic acid. Mice with expression of CYP2J2 in cardiomyocytes (…