The success of Mycobacterium tuberculosis as a pathogen is largely attributable to its ability
to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged …

… McKinney JD, Pedersen L. Biological activity of … Waller C, McKinney JD. Comparative
molecular field analysis of … Chae K, McKinney JD. Molecularcomplexes of thyroid hormone …

Phenotypic heterogeneity, defined as metastable variation in cellular parameters generated
by epigenetic mechanisms, is crucial for the persistence of bacterial populations under …

Mycobacterium tuberculosis claims more human lives each year than any other bacterial
pathogen. Infection is maintained in spite of acquired immunity and resists eradication by …

Interferon-γ (IFN-γ) provides an essential component of immunity to tuberculosis by activating
infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (…

Genes involved in fatty acid catabolism have undergone extensive duplication in the genus
Mycobacterium, which includes the etiologic agents of leprosy and tuberculosis. Here, we …

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the
synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of …

Exposure of an isogenic bacterial population to a cidal antibiotic typically fails to eliminate a
small fraction of refractory cells. Historically, fractional killing has been attributed to …

Neonatal effects of transplacental exposure to polychlorinated biphenyls (PCBs) and
dichlorodiphenyl dichloroethene (DDE) were examined in a study of 912 infants. Birth weight, head …

A series of polychlonnated hydroxybiphenyls(PCBs) has been tested for their binding activity
to soluble uterine estrogen recep-tor protein. Competitive binding analysis was performed …