Microsomal triglyceride transfer protein (MTP) is a lipid transfer protein that is required for
the assembly and secretion of very low density lipoproteins by the liver and chylomicrons by …

BMS-200475 was recently shown to have potent antiviral activity against hepatitis B virus (50%
effective concentration = 3.7 nM; 50% cytotoxic concentration = 30 μM). In metabolic …

R-phosphonosulfonic acids (R-PSAs) are potent inhibitors of squalene synthase in vitro. A
number of these inhibitors exhibited promising in vivo activity on intravenous dosing. However…

Inhibitors of squalene synthase have recently received considerable attention in the search
for new antihypercholesterolemic agents. 1 We disclose herein the discovery of a new family …

(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)
(MaxiPost, BMS-204352) is a potent and specific opener for maxi-K channels and has …

This study describes the pharmacokinetic parameters of gemopatrilat, a potent vasopeptidase
inhibitor, in humans and the comparative biotransformation of the compound in rats, dogs, …

Abstract Development of Aripiprazole as an oral treatment of schizophrenia required the
synthesis of a suitably labeled drug product for use in human metabolism and pharmacokinetic …

Omapatrilat, a potent vasopeptidase inhibitor, is currently under development for the treatment
of hypertension and congestive heart failure. This study describes the plasma profile …

A reliable synthesis of 14 C labeled 6‐hydroxy‐buspirone is described. The molecule belongs
to a unique class of compounds with the potential for anxiolytic activity. A radiolabeled …

1, 3-Bridged naphthalenes of type 3 and 4, in which the minimum value of n is 2, have been
prepared in high yield, Steric constraint in such metacyclophanes causes distortion or …