User profiles for J. Latham

John Paul Latham

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Verified email at imperial.ac.uk
Cited by 5200

New developments in RiPP discovery, enzymology and engineering

…, C Hill, S Kim, J Koehnke, JA Latham… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

[HTML][HTML] The use of discrete fracture networks for modelling coupled geomechanical and hydrological behaviour of fractured rocks

Q Lei, JP Latham, CF Tsang - Computers and Geotechnics, 2017 - Elsevier
We present a discussion of the state-of-the-art on the use of discrete fracture networks (DFNs)
for modelling geometrical characteristics, geomechanical evolution and hydromechanical (…

Cross-regulation of histone modifications

JA Latham, SYR Dent - Nature structural & molecular biology, 2007 - nature.com
Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation, …

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

LC Bock, LC Griffin, JA Latham, EH Vermaas, JJ Toole - nature, 1992 - nature.com
APTAMERS 1 are double-stranded DNA or single-stranded RNA molecules that bind specific
molecular targets. Large randomly generated populations can be enriched in aptamers by …

[HTML][HTML] Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

…, M Appleby, ME Brunkow, JA Latham - The EMBO …, 2003 - embopress.org
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic
bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease …

The interaction of falling water drops: coalescence

…, SG Jennings, J Latham - Proceedings of the …, 1972 - royalsocietypublishing.org
Experimental studies have been conducted of the interaction of falling water drops of radii R
and r (R > r), density p and surface tension σ colliding in air with a relative velocity U and a …

The influence of entrainment on the evolution of cloud droplet spectra: I. A model of inhomogeneous mixing

MB Baker, RG Corbin, J Latham - Quarterly Journal of the …, 1980 - Wiley Online Library
In this, the first of two related papers, we present calculations of the growth of a population
of condensate droplets rising above cloud base within small cumuli which are entraining …

[PDF][PDF] The most detailed portrait of Earth

O Arino, P Bicheron, F Achard, J Latham, R Witt… - Eur. Space …, 2008 - researchgate.net
In addition to being made fully available to the public upon its completion in September this
year, scientists will use the data to plot worldwide land-cover trends, study natural and …

[HTML][HTML] A unified phylogeny-based nomenclature for histone variants

…, AG Ladurner, D Landsman, JA Latham… - Epigenetics & …, 2012 - Springer
Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin
structure. The known number of such variants has greatly increased in recent years, but the …

Defining the inside and outside of a catalytic RNA molecule

JA Latham, TR Cech - Science, 1989 - science.org
Ribozymes are RNA molecules that catalyze biochemical reactions. Fe(II)-EDTA, a solvent-based
reagent which cleaves both double- and single-stranded RNA, was used to investigate …