Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly
in industrialized countries. AMD is a multifactorial disease influenced by both genetic and …

purpose. To compare the temporal and spatial expression patterns of amyloid precursor
protein (APP), amyloid-β deposits, inflammatory chemokines, and apoptosis in the retina of a …

Objectives : The purpose of this study was to investigate whether peripheral endothelial
dysfunction could predict the occurrence of cardiovascular events in patients with heart failure (…

Objectives : The aim of this study was to investigate the antiatherogenic effects of the dipeptidyl
peptidase-4 inhibitor, des-fluoro-sitagliptin (DFS). Background : The new class of anti–…

Objectives : We investigated the utility of digital reactive hyperemia peripheral arterial
tonometry (RH-PAT) in predicting ischemic heart disease (IHD), including obstructive coronary …

Objectives : This study investigated the clinical significance of plasma pentraxin 3 (PTX3)
levels in patients with heart failure with normal ejection fraction (HFNEF) and whether PTX3 is …

Rationale Age-related macular degeneration (AMD) is one of the leading causes of blindness
among the elderly. Due to its complex etiology, current treatments have been insufficient. …

Background: Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes
mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial …

Background Endothelial dysfunction is a key component of vascular vulnerability. Reactive
hyperemia index ( RHI ), as assessed by the peripheral arterial tonometry, can noninvasively …

Diabetic Retinopathy (DR) is an insidious neurovascular disorder secondary to chronic
glycemic dysregulation in elderly diabetic patients. In the later stages of DR, the disease …