Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification,
often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin …

CYP1A1, CYP1A2, and CYP1B1 have a high degree of sequence similarity, similar substrate
selectivities and induction characteristics. However, experiments suggest that there are …

This report summarizes a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics at Experimental Biology held April 20-24 in Boston, MA. …

Previous studies have shown that the presence of one P450 enzyme can affect the function
of another. The goal of the present study was to determine if P450 enzymes are capable of …

P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with
the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when …

Genetic variations in POR, encoding NADPH-cytochrome P450 oxidoreductase (CYPOR),
can diminish the function of numerous cytochromes P450, and also have the potential to block …

Cytochromes P450s (P450s) catalyze oxygenation reactions via interactions with their redox
partners. However, other proteins, particularly other P450s, also have been shown to form …

Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum–bound
enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to …

Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex
that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a …

ID 25945 Poster Board 390 CYP1A1, CYP1A2, and CYP1B1 share high amino acid
sequence similarity, substrate selectivity, and induction characteristics. Despite this, there are …