Disposition and biotransformation of the antipsychotic agent olanzapine in humans

…, RM Goodwin, D Tupper, JT Callaghan… - Drug Metabolism and …, 1997 - ASPET
Disposition and biotransformation of the new antipsychotic agent olanzapine (OLZ) were
studied in six male healthy volunteers after a single oral dose of 12.5 mg containing 100 μCi of [ …

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing

…, MTM Lee, TE Klein, JT Callaghan - Clinical …, 2014 - Wiley Online Library
Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large
interpatient variability, partly due to genetic variations in the gene encoding cytochrome P450 (…

[HTML][HTML] Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions

…, SD Karnik, X Li, SD Hall, Y Jin, JT Callaghan… - 2012 - journals.plos.org
Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we
combined a literature discovery approach with analysis of a large electronic medical record …

[HTML][HTML] Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers

…, PJ Loehrer, R Pili, N Hanna, JT Callaghan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Results From April 2014–October 2015, 168 patients were evaluated and 101 patients
achieved adequate clinical follow-up for analysis. 19 of 44 (43.2%) patients treated with …

Pergolide, a potent long‐acting dopamine‐receptor agonist

…, R Crabtree, JT Callaghan - Clinical Pharmacology & …, 1980 - Wiley Online Library
After single doses (100 to 400 µg orally), pergolide, a synthetic ergot, reduced basal plasma
prolactin levels in normal subjects in a dose‐related manner. This effect persisted for more …

Mixture interpretation: defining the relevant features for guidelines for the assessment of mixed DNA profiles in forensic casework

B Budowle, AJ Onorato, TF Callaghan… - Journal of Forensic …, 2009 - Wiley Online Library
Currently in the United States there is little direction for what constitutes sufficient guidelines
for DNA mixture interpretation. While a standardized approach is not possible or desirable, …

Massively parallel sequencing of complete mitochondrial genomes from hair shaft samples

…, S Nagl, C Xavier, M Eduardoff, TC Callaghan… - Forensic Science …, 2015 - Elsevier
Though shed hairs are one of the most commonly encountered evidence types, they are
among the most limited in terms of DNA quantity and quality. As a result, DNA testing has …

Random walker ranking for NCAA division IA football

T Callaghan, PJ Mucha, MA Porter - The American Mathematical …, 2007 - Taylor & Francis
1. INTRODUCTION. The Bowl Championship Series (BCS) agreement was created in 1998
to match the top two NCAA Division IA college football teams in a National Championship …

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

…, T Calahan, R Geocadin, M Parish, J Frey… - The Lancet …, 2019 - thelancet.com
Background Iron from haemolysed blood is implicated in secondary injury after intracerebral
haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in …

Associations between perfectionism and symptoms of anxiety, obsessive-compulsive disorder and depression in young people: a meta-analysis

J Lunn, D Greene, T Callaghan… - Cognitive behaviour …, 2023 - Taylor & Francis
Perfectionism is a transdiagnostic process contributing to the onset and maintenance of
anxiety, obsessive-compulsive disorder (OCD) and depression. The aim of this systematic …