Disposition and biotransformation of the antipsychotic agent olanzapine in humans
…, RM Goodwin, D Tupper, JT Callaghan… - Drug Metabolism and …, 1997 - ASPET
Disposition and biotransformation of the new antipsychotic agent olanzapine (OLZ) were
studied in six male healthy volunteers after a single oral dose of 12.5 mg containing 100 μCi of [ …
studied in six male healthy volunteers after a single oral dose of 12.5 mg containing 100 μCi of [ …
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing
Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large
interpatient variability, partly due to genetic variations in the gene encoding cytochrome P450 (…
interpatient variability, partly due to genetic variations in the gene encoding cytochrome P450 (…
[HTML][HTML] Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions
Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we
combined a literature discovery approach with analysis of a large electronic medical record …
combined a literature discovery approach with analysis of a large electronic medical record …
[HTML][HTML] Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers
…, PJ Loehrer, R Pili, N Hanna, JT Callaghan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Results From April 2014–October 2015, 168 patients were evaluated and 101 patients
achieved adequate clinical follow-up for analysis. 19 of 44 (43.2%) patients treated with …
achieved adequate clinical follow-up for analysis. 19 of 44 (43.2%) patients treated with …
Pergolide, a potent long‐acting dopamine‐receptor agonist
…, R Crabtree, JT Callaghan - Clinical Pharmacology & …, 1980 - Wiley Online Library
After single doses (100 to 400 µg orally), pergolide, a synthetic ergot, reduced basal plasma
prolactin levels in normal subjects in a dose‐related manner. This effect persisted for more …
prolactin levels in normal subjects in a dose‐related manner. This effect persisted for more …
Mixture interpretation: defining the relevant features for guidelines for the assessment of mixed DNA profiles in forensic casework
B Budowle, AJ Onorato, TF Callaghan… - Journal of Forensic …, 2009 - Wiley Online Library
Currently in the United States there is little direction for what constitutes sufficient guidelines
for DNA mixture interpretation. While a standardized approach is not possible or desirable, …
for DNA mixture interpretation. While a standardized approach is not possible or desirable, …
Massively parallel sequencing of complete mitochondrial genomes from hair shaft samples
…, S Nagl, C Xavier, M Eduardoff, TC Callaghan… - Forensic Science …, 2015 - Elsevier
Though shed hairs are one of the most commonly encountered evidence types, they are
among the most limited in terms of DNA quantity and quality. As a result, DNA testing has …
among the most limited in terms of DNA quantity and quality. As a result, DNA testing has …
Random walker ranking for NCAA division IA football
1. INTRODUCTION. The Bowl Championship Series (BCS) agreement was created in 1998
to match the top two NCAA Division IA college football teams in a National Championship …
to match the top two NCAA Division IA college football teams in a National Championship …
Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial
…, T Calahan, R Geocadin, M Parish, J Frey… - The Lancet …, 2019 - thelancet.com
Background Iron from haemolysed blood is implicated in secondary injury after intracerebral
haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in …
haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in …
Associations between perfectionism and symptoms of anxiety, obsessive-compulsive disorder and depression in young people: a meta-analysis
J Lunn, D Greene, T Callaghan… - Cognitive behaviour …, 2023 - Taylor & Francis
Perfectionism is a transdiagnostic process contributing to the onset and maintenance of
anxiety, obsessive-compulsive disorder (OCD) and depression. The aim of this systematic …
anxiety, obsessive-compulsive disorder (OCD) and depression. The aim of this systematic …