Background T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice
by high doses of reactive hapten is mediated by suppressor cells that release antigen-specific …

This paper reviews evidence that changes in the functioning of the brain dopaminergic system
affect liver cytochrome P450 (CYP) expression (CYP1A, CYP2B, CYP2C11 and CYP3A in …

The central and peripheral nervous systems are important factors influencing the
functioning of liver cytochrome P450 (CYP). It has been shown that changes in the brain …

The present study was aimed at assessing individual contributions of the phospholipid
binding and lysosomal trapping to the total tissue uptake of psychotropic drugs with different …

The purpose of the present study was to investigate the contribution of lysosomal trapping to
the total tissue uptake of thioridazine and to potential drug distribution interactions between …

… Maj J: Antidepressant given repeatedly: pharmacological evaluation of their action. Pol J …
Rogóż Z, Dziedzicka-Wasylewska M, Daniel WA, Wójcikowski J, Dudek D, Wróbel A, Zięba A: …

Genes encoding different cytochrome P450 (CYP) isoforms are regulated by endogenous
hormones (eg pituitary hormones, thyroid hormones, glucocorticoids) which are all under …

Currently used antipsychotics are characterized by multireceptor mode of action. While
antagonism of dopamine D 2 receptors is responsible for the alleviation of “positive” symptoms of …

The aim of the present study was to identify cytochrome P450 (CYP) isoenzymes involved in
the 5-sulfoxidation, mono-N-demethylation and di-N-demethylation of the aliphatic-type …

A series of N1-azinylsulfonyl-3-(1,2,3,6,tetrahyrdopyridin-4-yl)-1H-indole derivatives was
designed to obtain highly potent 5-HT 6 receptor ligands. The study allowed for the …