Effects of phthalic acid esters on the liver and thyroid.

…, SC Price, A Nunn, P Grasso, JW Bridges - Environmental …, 1986 - ehp.niehs.nih.gov
The effects, over periods from 3 days to 9 months of administration, of diets containing di-2-ethylhexyl
phthalate are very similar to those observed in rats administered diets containing …

Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria

RH Adamson, JW Bridges, ME Evans… - Biochemical …, 1970 - portlandpress.com
1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2.
In man and three species of Old World monkeys, ie rhesus monkey, baboon and green …

Time and dose-response study of the effects on rats of the plasticizer di (2-ethylhexyl) phthalate

…, SC Price, RH Hinton, P Grasso, JW Bridges - Toxicology and Applied …, 1985 - Elsevier
Groups of male and groups of female Wistar albino rats were administered diets containing
sufficient di(2-ethylhexyl) phthalate (DEHP) to ensure intakes of either 1000, 200, or 50 mg/kg…

The enzymic isolation of adult rat hepatocytes in a functional and viable state

…, CA Jones, P Wiebkin, P Bellemann, JW Bridges - Analytical …, 1976 - Elsevier
Various methods for the preparation of rat hepatocyte suspensions have been compared
with regard to cell yield and viability index. A modified method of collagenase/hyaluronidase …

Identification of the proximate peroxisome proliferator (s) derived from di (2-ethylhexyl) phthalate

AM Mitchell, JC Lhuguenot, JW Bridges… - Toxicology and applied …, 1985 - Elsevier
A primary rat hepatocyte culture system was utilized to determine the proximate peroxisome
proliferator(s) derived from di(2-ethylhexyl) phthalate (DEHP). DEHP was administered to …

Comparison of the short-term effects of di (2-ethylhexyl) phthalate, di (n-hexyl) phthalate, and di (n-octyl) phthalate in rats

…, FE Mitchell, P Grasso, RH Hinton, JW Bridges - Toxicology and applied …, 1985 - Elsevier
This study compares changes in the livers of rats treated with di(2-ethylhexyl) phthalate (DEHP)
and its straight-chain analogs di(n-hexyl) phthalate (DnHP) and di(n-octyl phthalate (…

Factors influencing peroxisome proliferation in cultured rat hepatocytes

AM Mitchell, JW Bridges, CR Elcombe - Archives of toxicology, 1984 - Springer
A primary rat hepatocyte culture system has been developed for the study of peroxisome
proliferation. Maximal induction of peroxisomal activity requires supplementation of the culture …

[HTML][HTML] Is the EU chemicals strategy for sustainability a green deal?

JW Bridges, H Greim, K van Leeuwen… - Regulatory toxicology …, 2023 - Elsevier
… Author links open overlay panel James W. Bridges a , Helmut Greim b , Kees van Leeuwen c
, Rainer Stegmann … Bridges and Prof. Greim. All other authors contributed to the manuscript. …

Comparison of two methods of preparing enzyme-antibody conjugates: application of these conjugates for enzyme immunoassay

…, AD Simmonds, M Simmons, JW Bridges… - Analytical …, 1979 - Elsevier
Two methods of preparing enzyme-antibody conjugates were evaluated. High yields of
conjugate were obtained with both methods. The first procedure utilizes the homobifunctional …

Benzo (a) pyren-3-yl hydrogen sulphate, a major ethyl acetate-extractable metabolite of benzo (a) pyrene in human, hamster and rat lung cultures

…, SM Haws, BP Moore, JW Bridges - Biochemical Pharmacology, 1976 - Elsevier
Benzo(a)pyrene is metabolised by human bronchial epithelium to ethyl acetate-extractable
metabolites which co-chromatograph with 9,10-dihydro-9,10-dihydroxybenzo(a) pyrene and 7…