Publisher Summary The method for lowering tissue glutathione (GSH) levels involves the
administration of compounds that react enzymically with GSH to form conjugates. The …

The balance between detoxification and bioactivation of a compound in a particular species
or organ is highly dependent on the relative amounts and activities of the different forms of …

Many of the biotransformation reactions which have been described for xenobiotic substances
in mammals have been demonstrated in fish in both in vitro and in vivo experiments. …

Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …

Heme metabolism normally involves enzymatic conversion to biliverdin and subsequently to
bilirubin, catalyzed by heme oxygenase and biliverdin reductase, respectively. We …

Objectives To determine whether unprocessed grapefruit can cause a drug interaction, whether
the active ingredients are naturally occurring, and whether specific furanocoumarins or …

Objectives: Our objective was to assess the importance of bergamottin in drug interactions
through comparisons between grapefruit juice and lime juice and the potential for drug …

Objective To test whether naringin or 6′,7′‐dihydroxybergamottin is a major active
substance in grape‐fruit juice‐felodipine interaction in humans. Methods Grapefruit juice was …

Anticonvulsant hypersensitivity syndrome (AHS), also known by the other names drug rash (reaction)
with eosinophilia and systemic symptoms (DRESS) and drug-induced …

The horticultural sector has undergone tremendous growth in Kenya and is now the second
largest foreign income earning sector in the country. Lake Naivasha is the hub of large scale …