Genetic Variants in the UDP-glucuronosyltransferase 1A1 Gene Predict the Risk of Severe Neutropenia of Irinotecan
…, T Karrison, L Janisch, J Ramírez… - Journal of Clinical …, 2004 - ascopubs.org
Purpose Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase
1A1 (UGT1A1) catalyzes the glucuronidation of the active …
1A1 (UGT1A1) catalyzes the glucuronidation of the active …
Phenotype‐genotype correlation of in vitro SN‐38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter …
…, D Hall, S Das, MA Mortell, J Ramírez… - Clinical …, 1999 - Wiley Online Library
… Jacqueline Ramírez MS… Jacqueline Ramírez MS … Jacqueline Ramírez MS …
[HTML][HTML] Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
… HNF1A 79A>C genotyping was performed by SBE with DHLPC as previously described (Ramírez
J, Mirkov S, Zhang W, et al. Pharmacogenomics J 8:152-161, 2008). The UGT1A1*28 allele …
J, Mirkov S, Zhang W, et al. Pharmacogenomics J 8:152-161, 2008). The UGT1A1*28 allele …
A pharmacogenetic study of uridine diphosphate–glucuronosyltransferase 2B7 in patients receiving morphine
…, F Innocenti, S Das, C Cheng, J Ramírez… - Clinical …, 2003 - Wiley Online Library
We investigated the variation in the uridine diphosphate–glucuronosyltransferase 2B7 (UGT2B7)
gene in patients receiving patient‐controlled analgesia with morphine. UGT2B7 was …
gene in patients receiving patient‐controlled analgesia with morphine. UGT2B7 was …
Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups
F Innocenti, C Grimsley, S Das, J Ramírez… - Pharmacogenetics …, 2002 - journals.lww.com
Genetic variation in UDP-glucuronosyltransferase 1A1 (UGT1A1) expression has several
important clinical implications. UGT1A1 basal transcription is affected by a polymorphic (TA) n …
important clinical implications. UGT1A1 basal transcription is affected by a polymorphic (TA) n …
[HTML][HTML] Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer
F Innocenti, RL Schilsky, J Ramírez… - Journal of clinical …, 2014 - ncbi.nlm.nih.gov
Purpose The risk of severe neutropenia from treatment with irinotecan is related in part to
UGT1A1* 28, a variant that reduces the elimination of SN-38, the active metabolite of irinotecan…
UGT1A1* 28, a variant that reduces the elimination of SN-38, the active metabolite of irinotecan…
Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea
E Gupta, TM Lestingi, R Mick, J Ramirez, EE Vokes… - Cancer research, 1994 - AACR
Irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11) is
hydrolyzed by the enzyme carboxyl esterase to 7-ethyl-10-hydroxycamptothecin (SN-38), …
hydrolyzed by the enzyme carboxyl esterase to 7-ethyl-10-hydroxycamptothecin (SN-38), …
[HTML][HTML] Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue
…, ER Gamazon, JD Smith, S Mirkov, J Ramirez… - PLoS …, 2011 - journals.plos.org
The discovery of expression quantitative trait loci (“eQTLs”) can help to unravel genetic
contributions to complex traits. We identified genetic determinants of human liver gene …
contributions to complex traits. We identified genetic determinants of human liver gene …
Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases
We aimed to investigate and compare the effects of erlotinib and gefitinib on UDP-glucuronosyltransferase
(UGT) activities and to quantitatively evaluate their drug-drug interaction (DDI…
(UGT) activities and to quantitatively evaluate their drug-drug interaction (DDI…
[HTML][HTML] Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
…, X Jiang, L Janisch, S Das, J Ramirez… - Journal of clinical …, 2008 - ncbi.nlm.nih.gov
… Rudin, Wanqing Liu, Apurva Desai, Linda Janisch, Soma Das, Jacqueline Ramirez,
Balasubramanian Poonkuzhali, Erin Schuetz, Donna Lee Fackenthal, Peixian Chen …
Balasubramanian Poonkuzhali, Erin Schuetz, Donna Lee Fackenthal, Peixian Chen …