Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy
…, HJ Song, YG Kang, JW Kim, J Lee… - Journal of medicinal …, 2014 - ACS Publications
Although the etiology of Parkinson’s disease (PD) remains elusive, recent studies suggest
that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) …
that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) …
A clean, more efficient method for in-solution digestion of protein mixtures without detergent or urea
Proteolytic digestion of a complicated protein mixture from an organelle or whole-cell lysate
is usually carried out in a dilute solution of a denaturing buffer, such as 1−2 M urea. Urea …
is usually carried out in a dilute solution of a denaturing buffer, such as 1−2 M urea. Urea …
Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson's disease therapy
…, JW Kim, SY Woo, C Lee, SM Han, J Lee… - Journal of Medicinal …, 2018 - ACS Publications
We previously developed a novel series of vinyl sulfones as nuclear factor erythroid 2-related
factor 2 (Nrf2) activators with therapeutic potential for Parkinson’s disease (PD). However, …
factor 2 (Nrf2) activators with therapeutic potential for Parkinson’s disease (PD). However, …
[HTML][HTML] Influence of mobile phase composition on the analytical sensitivity of LC–ESI–MS/MS for the concurrent analysis of bisphenols, parabens, chlorophenols …
KM Lee, SM Han, HJ Lee, M Kang, TY Jeong… - Environmental …, 2023 - Elsevier
Phenols are significant environmental endocrine disruptors that can have adverse health
effects on exposed individuals. Correlating phenol exposure to potential health implications …
effects on exposed individuals. Correlating phenol exposure to potential health implications …
Simultaneous quantitation of enalapril and enalaprilat in human plasma by 96‐well solid‐phase extraction and liquid chromatography/tandem mass spectrometry
J Lee, J Son, M Lee, KT Lee… - Rapid communications in …, 2003 - Wiley Online Library
A sensitive and rapid method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS)
combined with rapid solid‐phase extraction (SPE) has been developed and …
combined with rapid solid‐phase extraction (SPE) has been developed and …
[PDF][PDF] Astrocytes control sensory acuity via tonic inhibition in the thalamus
Sensory discrimination is essential for survival. However, how sensory information is finely
controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity …
controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity …
Simultaneous analysis of 210 prohibited substances in human urine by ultrafast liquid chromatography/tandem mass spectrometry in doping control
…, EJ Cha, KM Lee, HJ Kim, SW Lee… - … in mass spectrometry, 2015 - Wiley Online Library
RATIONALE Doping analysis is a two‐step process consisting of a screening step for prohibited
substances and a confirmation step to verify the presence of specific substances found …
substances and a confirmation step to verify the presence of specific substances found …
[HTML][HTML] Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS
IMAC in combination with mass spectrometry is a promising approach for global analysis of
protein phosphorylation. Nevertheless this approach suffers from two shortcomings: …
protein phosphorylation. Nevertheless this approach suffers from two shortcomings: …
Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model
S Kim, ANI Viswanath, JH Park, HE Lee, AY Park… - …, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by abnormal
movement, including slowed movements, shuffling gait, lack of balance, and tremor. Oxidative …
movement, including slowed movements, shuffling gait, lack of balance, and tremor. Oxidative …
Development and investigation of a QuEChERS-based method for determination of phthalate metabolites in human milk
…, HD Cho, J Kim, JY Lee, Y Lee, E Jo, J Lee… - … of Pharmaceutical and …, 2020 - Elsevier
Phthalates are commonly used as plasticizers and are known as risk factors toward several
conditions such as cancer, birth defects, and endocrine disruption. Biomonitoring of …
conditions such as cancer, birth defects, and endocrine disruption. Biomonitoring of …