Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy

…, HJ Song, YG Kang, JW Kim, J Lee… - Journal of medicinal …, 2014 - ACS Publications
Although the etiology of Parkinson’s disease (PD) remains elusive, recent studies suggest
that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) …

A clean, more efficient method for in-solution digestion of protein mixtures without detergent or urea

SC Kim, Y Chen, S Mirza, Y Xu, J Lee… - Journal of proteome …, 2006 - ACS Publications
Proteolytic digestion of a complicated protein mixture from an organelle or whole-cell lysate
is usually carried out in a dilute solution of a denaturing buffer, such as 1−2 M urea. Urea …

Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson's disease therapy

…, JW Kim, SY Woo, C Lee, SM Han, J Lee… - Journal of Medicinal …, 2018 - ACS Publications
We previously developed a novel series of vinyl sulfones as nuclear factor erythroid 2-related
factor 2 (Nrf2) activators with therapeutic potential for Parkinson’s disease (PD). However, …

[HTML][HTML] Influence of mobile phase composition on the analytical sensitivity of LC–ESI–MS/MS for the concurrent analysis of bisphenols, parabens, chlorophenols …

KM Lee, SM Han, HJ Lee, M Kang, TY Jeong… - Environmental …, 2023 - Elsevier
Phenols are significant environmental endocrine disruptors that can have adverse health
effects on exposed individuals. Correlating phenol exposure to potential health implications …

Simultaneous quantitation of enalapril and enalaprilat in human plasma by 96‐well solid‐phase extraction and liquid chromatography/tandem mass spectrometry

J Lee, J Son, M Lee, KT Lee… - Rapid communications in …, 2003 - Wiley Online Library
A sensitive and rapid method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS)
combined with rapid solid‐phase extraction (SPE) has been developed and …

[PDF][PDF] Astrocytes control sensory acuity via tonic inhibition in the thalamus

…, KD Park, BE Yoon, J Lee, Y Li, H Lee, YC Bae, CJ Lee… - Neuron, 2020 - cell.com
Sensory discrimination is essential for survival. However, how sensory information is finely
controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity …

Simultaneous analysis of 210 prohibited substances in human urine by ultrafast liquid chromatography/tandem mass spectrometry in doping control

…, EJ Cha, KM Lee, HJ Kim, SW Lee… - … in mass spectrometry, 2015 - Wiley Online Library
RATIONALE Doping analysis is a two‐step process consisting of a screening step for prohibited
substances and a confirmation step to verify the presence of specific substances found …

[HTML][HTML] Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS

J Lee, Y Xu, Y Chen, R Sprung, SC Kim, S Xie… - Molecular & Cellular …, 2007 - ASBMB
IMAC in combination with mass spectrometry is a promising approach for global analysis of
protein phosphorylation. Nevertheless this approach suffers from two shortcomings: …

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model

S Kim, ANI Viswanath, JH Park, HE Lee, AY Park… - …, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by abnormal
movement, including slowed movements, shuffling gait, lack of balance, and tremor. Oxidative …

Development and investigation of a QuEChERS-based method for determination of phthalate metabolites in human milk

…, HD Cho, J Kim, JY Lee, Y Lee, E Jo, J Lee… - … of Pharmaceutical and …, 2020 - Elsevier
Phthalates are commonly used as plasticizers and are known as risk factors toward several
conditions such as cancer, birth defects, and endocrine disruption. Biomonitoring of …