Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic
parasites that cause diseases such as sleeping sickness and leishmania and adversely affect …

The syntheses of nine new derivatives of 2,5-bis[4-(N-alkylamidino)phenyl]furans with
extended aromatic systems are reported. The interaction of these dicationic furans with poly(dA)*…

Fluorescence microscopy of trypanosomes from drug treated mice shows that biologically
active heterocyclic diamidines that target the DNA minor groove bind rapidly and specifically to …

This report offers a methodology for assessing, quantitatively, the risks of terrorism. The
purpose of the methodology is to support effective decision making to combat terrorism. The …

African sleeping sickness is a fatal parasitic disease, and all drugs currently in use for
treatment have strong liabilities. It is essential to find new, effective, and less toxic drugs, ideally …

The aromatic diamidine pentamidine has long been used to treat early-stage human African
trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown …

The antiprotozoal compound 1,5-di(4-amidinophenoxy)pentane (pentamidine) and 36 of its
analogs were screened for in vitro activity against Leishmania mexicana amazonensis clone …

Syntheses of several carbamate analogues of 2,5-bis(4-amidinophenyl)furan (1) under mild
conditions and their evaluation as prodrugs against Pneumocystis carinii pneumonia (PCP) …

DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent
antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-…

A series of 33 analogues of the anti-Pneumocystis carinii drug l, 5-bis (4-amidinophenoxy)
pentane (pentamidine) was synthesized for screening against a rat model of P. carinii …