Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and …

…, TJ Garrett, JL Cantone, RW Diters, JG Mitroka… - … of pharmacological and …, 2007 - Elsevier
INTRODUCTION: The properties and potential liabilities of drug candidate are investigated
in detailed ADME assays and in toxicity studies, where findings are placed in context of …

Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation …

M Zhu, W Zhao, N Vazquez, JG Mitroka - Journal of pharmaceutical and …, 2005 - Elsevier
TopCount, a microplate scintillation counter (MSC), has been recently employed as an off-line
liquid radiochromatographic detector for radioactive metabolite profile analysis. The …

A multiyear comparison of flipped-vs. lecture-based teaching on student success in a pharmaceutical science class

JG Mitroka, C Harrington, MJ DellaVecchia - Currents in Pharmacy …, 2020 - Elsevier
Background and purpose To gauge the potential effect of mode of content delivery on overall
student success in a pharmaceutical sciences course in a doctor of pharmacy program. …

Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans

RC Dockens, KS Santone, JG Mitroka… - Drug metabolism and …, 2000 - ASPET
Ifetroban is a potent and selective thromboxane receptor antagonist. This study was conducted
to characterize the pharmacokinetics, absolute bioavailability, and disposition of ifetroban …

Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans

D Zhang, W Zhao, VA Roongta, JG Mitroka… - Drug metabolism and …, 2004 - ASPET
MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one),
or BMS-204352)] is a potent and specific maxi-K channel opener for potential …

Oral Bioavailability and Disposition of [14C]Omapatrilat in Healthy Subjects

…, KM Soucek, D Behr, W Liao, JG Mitroka… - The Journal of …, 2001 - Wiley Online Library
The objective of this study was to determine the absolute oral bioavailability and disposition
of omapatrilat. This singledose, randomized, crossover study of 20 mg intravenous and 50 …

Defining reality: the potential role of pharmacists in assessing the impact of progesterone receptor modulators and misoprostol in reproductive health

DJ Harrison, JG Mitroka - Annals of Pharmacotherapy, 2011 - journals.sagepub.com
Medical abortion is increasingly heralded as an ideal method for decreasing maternal
mortality in health-care resource-deprived areas and as an answer to the shrinking pool of …

Cerebrospinal fluid retrieval in the conscious dog: a methods development study

…, KK Sadanaga, DE Burkett, JG Mitroka… - Journal of …, 1995 - Taylor & Francis
A chronic cerebrospinal fluid access system is described for use in the conscious sling-restrained
dog. In a pilot study of ten dogs, a fenestrated barium-impregnated silastic catheter …

BMS-180448, a novel glyburide-reversible cardioprotective agent, enhances postischemic recovery of contractile function in dogs.

…, CS Parham, DB Whigan, JG Mitroka - Journal of Pharmacology …, 1996 - ASPET
BMS-180448 has been found to retain the cardioprotective potency of its chemically related
analog, cromakalim, although having significantly less peripheral vasodilating activity. The …

[BOOK][B] Monochloroacetic acid lethality in the rat in relation to lactic acid accumulation in the cerebrospinal fluid

JG Mitroka - 1989 - search.proquest.com
… by JAMES G. MITROKA A d is ser ta tio n submitted to the Graduate School - New … Rosemary
Mitroka, who throughout the long and sometimes lean years of graduate school, proved to …