Background Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma,
suggesting that in utero changes related to vitamin D responsive genes might play a crucial …

Objective Methotrexate (MTX) has several enzymatic targets in the folate pathway. To better
understand the variability in response to MTX, we characterized the interindividual variability …

The formation of drug-protein adducts via metabolic activation and covalent binding may
stimulate an immune response or may result in direct cell toxicity. Protein covalent binding is a …

To date, implementation of precision medicine for children has been limited. Extrapolation
of adult experience streamlines pediatric drug development programs, and physiologically …

Background We aimed to identify novel genetic variants affecting asthma risk, since these
might provide novel insights into molecular mechanisms underlying the disease. Methods We …

Methotrexate is a folate analog that is used in the treatment of cancers (eg acute lymphoblastic
leukemia, non-Hodgkin lymphoma, osteosarcoma, and colon cancer) and autoimmune …

The exponential increase in the number of drugs used to treat infant and childhood
illnesses necessitates an understanding of the ontogeny of drug biotransformation for the …

Purpose This study aimed to provide comprehensive diagnostic and candidate analyses in
a pediatric rare disease cohort through the Genomic Answers for Kids program. Methods …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions (DDIs),
pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized. However, …

Objective To evaluate intraindividual variability and the effects of sex and menstrual cycle
phase on the activity of cytochrome P450 1A2 (CYP1A2), N‐acetyltransferase 2 (NAT2), and …