BRCA1 and BRCA2: different roles in a common pathway of genome protection

R Roy, J Chun, SN Powell - Nature Reviews Cancer, 2012 - nature.com
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work at …

Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway

J Chun, ES Buechelmaier… - Molecular and cellular …, 2013 - Taylor & Francis
The Rad51 paralogs are required for homologous recombination (HR) and the maintenance
of genomic stability. The molecular mechanisms by which the five vertebrate Rad51 …

Staphylococcus aureus Activation of Caspase 1/Calpain Signaling Mediates Invasion Through Human Keratinocytes

G Soong, J Chun, D Parker… - The Journal of infectious …, 2012 - academic.oup.com
The USA300 strains of Staphylococcus aureus are the major cause of skin and soft tissue
infection in the United States. Invasive USA300 infection has been attributed to several …

[HTML][HTML] Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity

G Soong, FJ Martin, J Chun, TS Cohen, DS Ahn… - Journal of Biological …, 2011 - ASBMB
Staphyococcus aureus and especially the epidemic methicillin-resistant S. aureus strains
cause severe necrotizing pneumonia. The mechanisms whereby these organisms invade …

[PDF][PDF] TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration

J Chun, A Prince - Cell host & microbe, 2009 - cell.com
Recruitment of polymorphonuclear leukocytes (PMNs) into the lungs in response to inhaled
pathogens is initiated by epithelial signaling, the activation of toll-like receptors (TLRs), and …

Activation of Ca2+-dependent signaling by TLR2

J Chun, A Prince - The Journal of Immunology, 2006 - journals.aai.org
Upon contact with airway epithelial cells, bacterial products activate Ca 2+ fluxes that are
required for induction of NF-κB-dependent gene expression. TLR2 is apically displayed on …

Ca2+ signaling in airway epithelial cells facilitates leukocyte recruitment and transepithelial migration

J Chun, A Prince - Journal of leukocyte biology, 2009 - academic.oup.com
Review on consequences of TLR2 signaling the activation of Ca2+-dependent proteases (calpains)
and link to junctional proteins to facilitate PMN migration into the airway lumen. In …

BRCA1 and BRCA2: important differences with common interests

R Roy, J Chun, SN Powell - Nature Reviews Cancer, 2012 - nature.com
The Opinion article we wrote (BRCA1 and BRCA2: different roles in a common pathway of
genome protection. Nature Rev. Cancer 12, 68–78 (2012)) 1 on the functions of BRCA1 and …

Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl) propane

J Chun, UM Kent, RM Moss, LM Sayre… - Drug metabolism and …, 2000 - ASPET
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, was tested for its
ability to inactivate cytochrome P450s (P450s) 2B1 and 2B6. PPP inactivated the 7-(benzyloxy)…

The effect of cyclosporin A on airway cell proinflammatory signaling and pneumonia

…, S Sokol, B Reddy, G Soong, J Chun… - American journal of …, 2005 - atsjournals.org
Cyclosporin A (CsA) blocks T cell activation by interfering with the Ca 2+ -dependent
phosphatase, calcineurin. Proinflammatory responses to bacteria that are activated by Ca 2+ -…