The expression of many genes involved in xenobiotic/drug metabolism and transport is
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …

Xenobiotic and drug metabolism and transport are managed by a large number of genes
coordinately regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon …

Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of
CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of …

The fully active dihydroxylated metabolite of vitamin D 3 induces the expression ofCYP3A4
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human …

In this report we show that submicromolar concentrations of dexamethasone enhance
pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human …

The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and
-2C19, was investigated in primary cultures of human hepatocytes. By the use of RNase …

Although CYP3A induction by dexamethasone has been extensively documented, its
mechanism is still unclear because both the role of the glucocorticoid receptor and the ability of …

Vitamin D controls calcium homeostasis and the development and maintenance of bones
through vitamin D receptor activation. Prolonged therapy with rifampicin or phenobarbital has …

The barbiturate phenobarbital induces the transcription of cytochromes P450 (CYPs) 2B
through the constitutive androstane receptor (CAR; NR1I3). CAR is a member of the nuclear …

Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human
liver, its mechanism of regulation is poorly known. In previous work, we have shown that …