User profiles for Jeffrey G. Sarver

Jeffrey Sarver

Professor of Pharmacology, The University of Toledo
Verified email at utoledo.edu
Cited by 988

[HTML][HTML] Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α

…, MP Morran, SO Adeosun, JG Sarver… - Journal of Biological …, 2020 - ASBMB
Activation of lipid-burning pathways in the fat-storing white adipose tissue (WAT) is a promising
strategy to improve metabolic health and reduce obesity, insulin resistance, and type II …

[HTML][HTML] The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

Z Li, NE Mbah, JH Overmeyer, JG Sarver, S George… - BMC cancer, 2019 - Springer
Background Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic
cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized …

Pharmacokinetic modeling

JP Byers, JG Sarver - Pharmacology, 2009 - Elsevier
Publisher Summary This chapter describes pharmacokinetic (PK) models that focus on how
the concentration of drug in the body changes with time. Blood flow and membrane …

Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid …

…, J Liu, C Bykowski, JA Trendel, JG Sarver… - … of chromatography A, 2007 - Elsevier
A rapid high-performance liquid chromatography method has been developed for
simultaneous determination of capecitabine and its metabolites: 5′-deoxy-5-fluorocytidine (5′-DFCR…

Estimating xenobiotic half-lives in humans from rat data: influence of log P.

JG Sarver, D White, P Erhardt… - Environmental health …, 1997 - ehp.niehs.nih.gov
The nature of empirical allometric expressions relating dispositional and kinetic parameters
for a given xenobiotic across multiple mammalian species is well known. It has also been …

Simultaneous determination of procaine and para-aminobenzoic acid by LC–MS/MS method

…, C Bykowski, JA Trendel, JG Sarver… - … of Chromatography B, 2007 - Elsevier
A sensitive high performance liquid chromatography tandem mass spectrometry (LC–MS/MS)
method has been developed for simultaneous determination of procaine and its …

Synthesis and evaluation of PPARδ agonists that promote osteogenesis in a human mesenchymal stem cell culture and in a mouse model of human osteoporosis

…, JR Mayo, JT Farris, B Heck, JG Sarver… - Journal of Medicinal …, 2021 - ACS Publications
We synthesized a directed library of compounds to explore the structure–activity
relationships of peroxisome proliferator-activated receptor δ (PPARδ) activation relative to …

Glyceollins, soy isoflavone phytoalexins, improve oral glucose disposal by stimulating glucose uptake

…, H Cao, D Bhatnagar, JG Sarver… - Journal of agricultural …, 2012 - ACS Publications
Soy glyceollins, induced during stress, have been shown to inhibit cancer cell growth in vitro
and in vivo. In the present study, we used prediabetic rats to examine the glyceollins effect …

Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that …

JG Sarver, WA Klis, JP Byers… - Journal of biomolecular …, 2002 - journals.sagepub.com
A microplate screening method has been developed to evaluate the effects of test agents on
the accumulation of the fluorescent P-glycoprotein (Pgp) substrates Hoechst 33342, …

Biomimetic syntheses and antiproliferative activities of racemic, natural (−), and unnnatural (+) glyceollin I

RS Khupse, JG Sarver, JA Trendel… - Journal of medicinal …, 2011 - ACS Publications
A 14-step biomimetic synthetic route to glyceollin I (1.5% overall yield) was developed and
deployed to produce the natural enantiomeric form in soy, its unnatural stereoisomer, and a …