The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …

This work describes the application of advanced microfabrication technologies including
silicon micromachining and polymer replica molding towards the field of tissue engineering of …

The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …

The advancement of tissue engineering is contingent upon the development and implementation
of advanced biomaterials. Conductive polymers have demonstrated potential for use …

Organ loss and failure is one of the most critical issues facing the healthcare industry in
developed nations. The shortage of available organ donors has driven the growth and …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-cochlear
barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Tissue engineering seeks to restore the function of diseased or damaged tissues through
the use of cells and biomaterial scaffolds. It is now apparent that the next generation of …

Controlling cell orientation and morphology through topographical patterning is a phenomenon
that is applicable to a wide variety of medical applications such as implants and tissue …

Mammalian cells respond to their substrates by complex changes in gene expression profiles,
morphology, proliferation and migration. We report that substrate nanotopography alters …