The objective of this study was to determine whether Toll-like receptor 4 (TLR4) has a role
in alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the …

Lysozymes contain a disproportionately large fraction of cationic residues, and are thereby
attracted toward the negatively charged surface of bacterial targets. Importantly, this …

The spread of drug-resistant bacterial pathogens is a growing global concern and has
prompted an effort to explore potential adjuvant and alternative therapies derived from nature's …

There is increasing urgency in the battle against drug-resistant bacterial pathogens, and
this public health crisis has created a desperate need for novel antimicrobial agents. …

Rationale: The death receptor Fas is critical for bacterial clearance and survival of mice after
Pseudomonas aeruginosa infection. Objectives: Fas ligand (FasL)–induced apoptosis is …

CYP2E1 has been reported to have an essential role in alcohol-mediated increases in
hepatic steatosis and acetaminophen hepatotoxicity. We found that pretreatment of Cyp2e1(-/-) …

Enzymatic activities are routinely used to identify the contribution of individual forms of
cytochrome P450 in a particular biotransformation. p-Nitrophenol O-hydroxylation (PNPH) has …

The objective of this study was to determine whether Toll-like Receptor 4 (TLR4) has a role
in alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the …

We have previously reported that obesity attenuates pulmonary inflammation in both patients
with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We …

Many cells can generate complementary traveling waves of actin filaments (F-actin) and
cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled …