Adductomic screening of hemoglobin adducts and monitoring of micronuclei in school-age children

H Carlsson, J Aasa, N Kotova, D Vare… - Chemical research in …, 2017 - ACS Publications
Electrophilic compounds/metabolites present in humans, originating from endogenous
processes or exogenous exposure, pose a risk to health effects through their reactions with …

[HTML][HTML] Internal doses of glycidol in children and estimation of associated cancer risk

J Aasa, E Vryonidis, L Abramsson-Zetterberg… - Toxics, 2019 - mdpi.com
The general population is exposed to the genotoxic carcinogen glycidol via food containing
refined edible oils where glycidol is present in the form of fatty acid esters. In this study, …

The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice

J Aasa, L Abramsson-Zetterberg, H Carlsson… - Food and chemical …, 2017 - Elsevier
Glycidol is a genotoxic animal carcinogen that has raised concern due to its presence in
food, as glycidyl fatty acid esters. Here we investigated the genotoxicity of glycidol in BalbC …

Measurement of micronuclei and internal dose in mice demonstrates that 3-monochloropropane-1, 2-diol (3-MCPD) has no genotoxic potency in vivo

J Aasa, M Törnqvist, L Abramsson-Zetterberg - Food and chemical …, 2017 - Elsevier
In this study 3-monochloropropane-1,2-diol (3-MCPD), a compound that appears as contaminant
in refined cooking oils, has been studied with regard to genotoxicity in vivo (mice) with …

Pathways to Identify Electrophiles In Vivo Using Hemoglobin Adducts: Hydroxypropanoic Acid Valine Adduct and Its Possible Precursors

E Vryonidis, I Karlsson, J Aasa… - Chemical Research …, 2022 - ACS Publications
Analytical methods and tools for the characterization of the human exposome by untargeted
mass spectrometry approaches are advancing rapidly. Adductomics methods have been …

[HTML][HTML] Applying a modified systematic review and integrated assessment framework (SYRINA)–a case study on triphenyl phosphate

TT Bui, J Aasa, K Abass, M Ågerstrand… - … Science: Processes & …, 2024 - pubs.rsc.org
This work presents a case study in applying a systematic review framework (SYRINA) to the
identification of chemicals as endocrine disruptors. The suitability and performance of the …

Quantification of the mutagenic potency and repair of glycidol-induced DNA lesions

J Aasa, D Vare, HV Motwani, D Jenssen… - … /Genetic Toxicology and …, 2016 - Elsevier
Glycidol (Gly) is an electrophilic low-molecular weight epoxide that is classified by IARC as
probably carcinogenic to humans. Humans might be exposed to Gly from food, eg refined …

[HTML][HTML] Cancer risk estimation of glycidol based on rodent carcinogenicity studies, a multiplicative risk model and in vivo dosimetry

J Aasa, F Granath, M Törnqvist - Food and chemical toxicology, 2019 - Elsevier
Here we evaluate a multiplicative (relative) risk model for improved cancer risk estimation of
genotoxic compounds. According to this model, cancer risk is proportional to the …

Effect of solvents on the time-dependent inhibition of CYP3A4 and the biotransformation of AZD3839 in human liver microsomes and hepatocytes

J Aasa, Y Hu, G Eklund, A Lindgren… - Drug Metabolism and …, 2013 - ASPET
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually
studied in human liver microsomes (HLM) by investigating whether the inhibitory potency is …

[BOOK][B] Rodenticide screening 2016–2018 Exposures in birds (raptors and gulls) and red foxes

J Aasa, J Sandberg, T Viktor, J Fång - 2019 - diva-portal.org
Rodenticides are biocidal products that are used in order to control rats and mice. This
screening study aims at investigating whether chemical substances belonging to the group …