Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator. Exogenous
FGF21 produces beneficial metabolic effects in animal models; however, the translation of …

Previous studies suggest that hepatic cytochrome P450 2E1 (CYP2E1) activity is increased
in individuals with chronic alcoholism, nonalcoholic steatohepatitis (NASH), and morbid …

The objective of this study is to assess the effectiveness of physiologically based
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles for the …

The objective of this study was to evaluate the performance of various allometric and in vitro–in
vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) are well-recognized
powerful tools that enable effective implementation of the learn-and-confirm …

The objective of this study was to evaluate the performance of various empirical, semimechanistic
and mechanistic methodologies with and without protein binding corrections for the …

Background Recent case reports suggest that consumption of ethanol may increase the risk
of liver injury induced by acetaminophen (INN, paracetamol). However, this possibility is at …

Background and Objective Dulaglutide is a long-acting glucagon-like peptide-1 receptor
agonist administered as once-weekly subcutaneous injections for the treatment of type 2 …

Neutralizing monoclonal antibodies (mAb), novel therapeutics for the treatment of coronavirus
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome‐coronavirus 2 (…

Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens
before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan …