There is a clear case for drug treatments to be selected according to the characteristics of
an individual patient, in order to improve efficacy and reduce the number and severity of …

We provide a demonstration in humans of the principle of pharmacometabonomics by showing
a clear connection between an individual's metabolic phenotype, in the form of a predose …

NMR spectroscopy of biofluids provides a wealth of information on the endogenous metabolic
processes in an organism. Details of the various types of biofluid and the types of NMR …

Publisher Summary This chapter reviews that the analysis of biofluids provides a unique
window into the biochemical status of a living organism since the composition of a given biofluid …

Metabonomics/metabolomics is an important science for the understanding of biological
systems and the prediction of their behaviour, through the profiling of metabolites. Two …

Pharmacogenomics is now over 50 years old and has had some impact in clinical practice,
through its use to select patient subgroups who will enjoy efficacy without side effects when …

Pharmacometabonomics describes the use of metabolic profiling of biofluids, tissues and
tissue extracts to predict, prior to dosing, the beneficial and adverse effects of an intervention …

Background Pharmacometabonomics is a new branch of science, first described in 2006
and defined as ‘the prediction of the effects of a drug on the basis of a mathematical model of …

Variable patient responses to drugs are a key issue for medicine and for drug discovery and
development. Personalized medicine, that is the selection of medicines for subgroups of …

Taurine is one of the most abundant amino acids in mammalian tissues. It is obtained from
the diet and by de novo synthesis from cysteic acid or hypotaurine. Despite the discovery in …