Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
JLF Rehmel, JA Eckstein, NA Farid, JB Heim… - Drug Metabolism and …, 2006 - ASPET
The biotransformation of prasugrel to R-138727 (2-[1-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic
acid) involves rapid deesterification to R-95913 (…
acid) involves rapid deesterification to R-95913 (…
Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans
P Yi, JF Rehmel, K Cassidy, C Hadden… - Drug Metabolism and …, 2012 - ASPET
The disposition and metabolism of isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate
(LY2452473; a selective androgen receptor …
(LY2452473; a selective androgen receptor …
Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors
…, MD Palmieri, MI Mitchell, TL Abraham, JF Rehmel… - Xenobiotica, 2014 - Taylor & Francis
The disposition and metabolism of a Chk-1 inhibitor (LY2603618) was characterized following
a 1-h intravenous administration of a single 250-mg dose of [ 14 C]LY2603618 (50 µCi) to …
a 1-h intravenous administration of a single 250-mg dose of [ 14 C]LY2603618 (50 µCi) to …
[CITATION][C] DRUG METABOLISM AND DISPOSITION
A PIKULEVA, H KIM, YJ YOON, JIH SHON - ASPET
[PDF][PDF] Prasugrel erhöht die endotheliale Bioverfügbarkeit von NO im Vergleich zu Clopidogrel bei Patienten mit instabiler Angina Pectoris
A Schlichting - 2014 - ediss.sub.uni-hamburg.de
Elektronen fließen von NADPH über FAD und FMN von der Reduktionsstelle zur Oxidationsstelle
der NO-Synthase. Hier interagieren sie mit dem Häm-Eisen und BH₄ am aktiven …
der NO-Synthase. Hier interagieren sie mit dem Häm-Eisen und BH₄ am aktiven …