Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms
L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …
[HTML][HTML] MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2
L Zhao, Y Qi, L Xu, X Tao, X Han, L Yin, J Peng - Redox biology, 2018 - Elsevier
Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti- tumor
effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely …
effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely …
[HTML][HTML] A review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases
C Luo, L Zou, H Sun, J Peng, C Gao, L Bao… - Frontiers in …, 2020 - frontiersin.org
Inflammatory diseases are caused by abnormal immune responses and are characterized
by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory …
by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory …
Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography
J Peng, G Fan, Z Hong, Y Chai, Y Wu - Journal of Chromatography A, 2005 - Elsevier
High-speed counter-current chromatography (HSCCC) with a solvent system composed of
ethyl acetate–n-butanol–water (2:1:3, v/v/v) was used to isolate and separate two C-…
ethyl acetate–n-butanol–water (2:1:3, v/v/v) was used to isolate and separate two C-…
[HTML][HTML] Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress
L Zhao, X Tao, Y Qi, L Xu, L Yin, J Peng - Redox biology, 2018 - Elsevier
Clinical application of doxorubicin (DOX) is limited because of its cardiotoxicity. Thus, exploration
of effective lead compounds against DOX-induced cardiotoxicity is necessary. The aim …
of effective lead compounds against DOX-induced cardiotoxicity is necessary. The aim …
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia–reperfusion injury through suppression of apoptosis and inflammation
S Zhang, Y Qi, Y Xu, X Han, J Peng, K Liu… - Neurochemistry …, 2013 - Elsevier
The neuroprotective effect and mechanism of the flavonoid-rich extract (FRE) from Rosa
laevigata Michx fruit on cerebral ischemia–reperfusion (I/R) injury were investigated. The …
laevigata Michx fruit on cerebral ischemia–reperfusion (I/R) injury were investigated. The …
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo
X Zhao, X Cong, L Zheng, L Xu, L Yin, J Peng - Toxicology letters, 2012 - Elsevier
The aim of the study was to investigate the protective effect of dioscin against APAP-induced
hepatotoxicity. In the in vitro tests, HepG2 cells were given APAP pretreatment with or …
hepatotoxicity. In the in vitro tests, HepG2 cells were given APAP pretreatment with or …
Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition
…, L Xu, Y Qi, Y Xu, H Li, Y Lin, K Liu, J Peng - Free Radical Biology …, 2015 - Elsevier
We previously reported the promising effect of dioscin against hepatic ischemia/reperfusion (I/R)
injury, but its effect on cerebral I/R injury remains unknown. In this work, an in vitro …
injury, but its effect on cerebral I/R injury remains unknown. In this work, an in vitro …
Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation
…, L Yin, X Tao, Y Zhen, XU Han, X Ma, K Liu, J Peng - Toxicology, 2017 - Elsevier
Dioscin shows active effects against renal ischemia/reperfusion injury and
lipopolysaccharide-induced inflammatory kidney injury, however, little is known concerning the role …
lipopolysaccharide-induced inflammatory kidney injury, however, little is known concerning the role …
Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice
…, L Xu, Y Qi, L Yin, Y Xu, Y Zhao, K Liu, J Peng - Food and Chemical …, 2013 - Elsevier
Protective effect of the total flavonoids (TFs) from Rosa laevigata Michx fruit against carbon
tetrachloride (CCl 4 )-induced hepatotoxicity in mice was investigated. Pretreatment with TFs …
tetrachloride (CCl 4 )-induced hepatotoxicity in mice was investigated. Pretreatment with TFs …