In many developing tissues, adjacent cells diverge in character so as to create a fine-grained
pattern of cells in contrasting states of differentiation. It has been proposed that such …

Preclinical and clinical studies were conducted to determine the metabolism and pharmacokinetics
of osimertinib and key metabolites AZ5104 and AZ7550. Osimertinib was designed …

Discussion If response sets are not stable over a period of time, it is idle to consider them as
even remotely useful measures of personality characteristics. This is a crucial question, for …

Objective Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established
treatment after the failure to standard of care based on steroids and vigabatrin. Converging …

Osimertinib is a third‐generation, central nervous system–active, epidermal growth factor
receptor–tyrosine kinase inhibitor (EGFR‐TKI) selective for EGFR‐TKI sensitizing and T790M …

This article presents a critical review of the Texas English Language Proficiency
Assessment System (TELPAS), a large scale standardized English language proficiency (ELP) …

The purposes of this research were to gain an understanding of how nurses in acute care
settings involve families of elderly patients in planning and giving care, and to determine the …

HE USE OF individually focused frameworks by health care professionals to discuss chronic
illness problems and behaviors poses major difficulties for both professionals and receivers …

Methods Healthy subjects (n= 94 enrolled, n= 92 completed) received single (10, 30, 100,
250, 500 or 1000mg) or multiple (125, 250, 500mg x7 days or 350mg x14 days), once-daily (…

Purpose Amuvatinib is a multi-targeted tyrosine kinase inhibitor with activity that also disrupts
DNA damage repair through suppression of homologous recombination protein Rad51. …