Young adult female rats are more susceptible to acetaminophen (APAP) induced nephrotoxicity
than are male rats. The purpose of the present study was to assess the contribution of …

Chronic progressive nephropathy is a spontaneous disease common among aging laboratory
rats, often making it difficult to distinguish age‐related from drug‐related effects in chronic …

Lactate dehydrogenase (LDH) release is frequently used as an end-point for cytotoxicity
studies. We have been unable to measure LDH release during studies using para-aminophenol …

Aminobenzotriazole (ABT) is a suicide substrate of both hepatic and pulmonary cytochromes
P450. The present studies were designed to compare the effects of ABT on hepatic and …

Acetaminophen (APAP) produces sex-dependent nephrotoxicity and hepatotoxicity in
young adult Sprague-Dawley (SD) rats and age-dependent toxicity in male rats. There is no …

The present studies were designed to investigate the susceptibility of LLC-PK 1 cells to
cytotoxicity induced by para-aminophenol (PAP) and the ability of antioxidants to prevent PAP-…

… Tarloff serves as an ad hoc reviewer for small business … Tarloff is heavily involved in
undergraduate and graduate toxicology … Tarloff’s primary research interests are defining the …

… old) F344 rats are more susceptible to APAPinduced nephrotoxicity than are 2- to 4month-old
rats (Beierschmitt el ai, 1986a,b). Changes in susceptibility are not reflected by altered …

Large doses of the cephalosporin antibiotic, cephaloridine, produce acute proximal tubular
necrosis in humans and in laboratory animals. Cephaloridine is actively transported into the …

Several chemicals, including para-aminophenol (PAP), produce kidney damage in the absence
of hepatic damage. Selective nephrotoxicity may be related to the ability of the kidney to …