User profiles for Jochen Klein

jochen klein

Mainz, Amarillo, Frankfurt
Verified email at em.uni-frankfurt.de
Cited by 6988

Robust independent validation of experiment and theory: Rivet version 3

…, C Gutschow, P Karczmarczyk, J Klein… - SciPost physics, 2020 - scipost.org
First released in 2010, the Rivet library forms an important repository for analysis code,
facilitating comparisons between measurements of the final state in particle collisions and …

Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes

…, V Chubanov, T Gudermann, J Klein… - Proceedings of the …, 2014 - National Acad Sciences
Chemosensory cells in the mucosal surface of the respiratory tract (“brush cells”) use the
canonical taste transduction cascade to detect potentially hazardous content and trigger local …

Excessive hippocampal acetylcholine levels in acetylcholinesterase‐deficient mice are moderated by butyrylcholinesterase activity

…, O Lockridge, NH Greig, J Klein - Journal of …, 2007 - Wiley Online Library
Central cholinergic systems are involved in a plethora of brain functions and are severely
and selectively damaged in neurodegenerative diseases such as Alzheimer’s disease and …

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients

…, M Hilgert, K Fassbender, A Schmitt, J Klein - Neurobiology of …, 2004 - Elsevier
Experimental and clinical studies give evidence for breakdown of membrane phospholipids
during neurodegeneration. In the present study, we measured the levels of …

Metabolism of boswellic acids in vitro and in vivo

P Krüger, R Daneshfar, GP Eckert, J Klein… - Drug metabolism and …, 2008 - ASPET
Boswellia serrata resin dry extract is among the few herbal remedies designated with an
orphan drug status for the treatment of peritumoral brain edema. In addition, boswellic acids (…

[PDF][PDF] Chemosensory cell-derived acetylcholine drives tracheal mucociliary clearance in response to virulence-associated formyl peptides

…, V Chubanov, T Gudermann, J Oberwinkler, J Klein… - Immunity, 2020 - cell.com
Mucociliary clearance through coordinated ciliary beating is a major innate defense removing
pathogens from the lower airways, but the pathogen sensing and downstream signaling …

In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery

…, WJ Geldenhuys, GA Gudelsky, J Klein… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Microdialysis is an important in vivo sampling technique, useful in assaying
extracellular tissue fluid. The technique has preclinical and clinical applications and is widely …

Phosphocholine-modified macromolecules and canonical nicotinic agonists inhibit ATP-induced IL-1β release

…, V Mathes, T Timm, S Lerner, J Klein… - The Journal of …, 2015 - journals.aai.org
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host
defense against infection. However, increased production of IL-1β plays a pathogenic role …

Functions and pathophysiological roles of phospholipase D in the brain

J Klein - Journal of neurochemistry, 2005 - Wiley Online Library
Ten years after the isoforms of mammalian phospholipase D (PLD), PLD1 and 2, were
cloned, their roles in the brain remain speculative but several lines of evidence now implicate …

Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain

J Klein, R Gonzalez, A Köppen, K Löffelholz - Neurochemistry international, 1993 - Elsevier
In the central nervous system, choline is an essential precursor of choline-containing
phospholipids in neurons and glial cells and of acetylcholine in cholinergic neurons. In order to …