This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …

A P-glycoprotein (P-gp) IC 50 working group was established with 23 participating
pharmaceutical and contract research laboratories and one academic institution to assess …

Purpose To establish in vitro and in silico models that predict clinical drug–drug interactions
(DDIs) with the OATP1B1 (SLCO1B1) transporter. Methods The inhibitory effect of 146 drugs …

Floating wave energy converters (WECs) operating in the resonance region are strongly
affected by non-linearities arising from the interaction between the waves, the WEC motion and …

This paper focuses on modelling snap loads in mooring cables. Snap loads are a known
problem for the established oil and gas industry, and they pose a major challenge to robust …

Mooring systems are required to keep floating wave energy converters (WECs) on station.
The mooring concept might impact the performance of the WEC, its cost and its integrity. With …

The paper presents incompressible Navier-Stokes simulations of the dynamics of a floating
wave energy converter (WEC) coupled to a high-order finite element solver for cable …

A new numerical model for simulating the dynamics of mooring cables is presented. The
model uses the hp formulation of the discontinuous Galerkin method. Verification against …

Accurate determination of potential drug–drug interaction mediated by efflux transporters (tDDI)
is crucial to assess the risk of pharmacokinetic interaction and toxicity of drugs. Passive …

The dynamic response of mooring cables for marine structures is scale-dependent, and perfect
dynamic similitude between full-scale prototypes and small-scale physical model tests is …