[HTML][HTML] Alectinib versus Crizotinib in Untreated ALK-Positive Non–Small-Cell Lung Cancer
…, E Mitry, S Golding, B Balas, J Noe… - … England Journal of …, 2017 - Mass Medical Soc
Background Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has
shown systemic and central nervous system (CNS) efficacy in the treatment of ALK-positive …
shown systemic and central nervous system (CNS) efficacy in the treatment of ALK-positive …
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1 …
J Noé, R Portmann, ME Brun, C Funk - Drug metabolism and disposition, 2007 - ASPET
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute
carriers are more and more recognized as being involved in hepatic elimination of many drugs …
carriers are more and more recognized as being involved in hepatic elimination of many drugs …
Functional expression of the canalicular bile salt export pump of human liver
J Noé, B Stieger, PJ Meier - Gastroenterology, 2002 - Elsevier
Background & Aims: Hepatic bile salt secretion is an essential function of vertebrate liver. Rat
and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile …
and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile …
[HTML][HTML] RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
…, Q Wang, H Hilton, JS Hang, J Noe… - … England Journal of …, 2012 - Mass Medical Soc
Background Cutaneous squamous-cell carcinomas and keratoacanthomas are common
findings in patients treated with BRAF inhibitors. Methods We performed a molecular analysis to …
findings in patients treated with BRAF inhibitors. Methods We performed a molecular analysis to …
[HTML][HTML] Updated efficacy and safety data and impact of the EML4-ALK fusion variant on the efficacy of alectinib in untreated ALK-positive advanced non–small cell …
…, R Dziadziuszko, S Peters, T Mok, J Noe… - Journal of Thoracic …, 2019 - Elsevier
Introduction At the prior data cutoff (February 9, 2017) the ALEX trial showed superior
investigator-assessed progression-free survival (PFS) for alectinib versus crizotinib in untreated, …
investigator-assessed progression-free survival (PFS) for alectinib versus crizotinib in untreated, …
[HTML][HTML] Assessment of a HER2 scoring system for colorectal cancer: results from a validation study
…, S Lonardi, V Zagonel, F Leone, J Noe… - Modern …, 2015 - nature.com
We sought to develop criteria for ERBB2-positivity (HER2) in colorectal cancer to ensure
accurate identification of ERBB2-amplified metastatic colorectal cancer patients suitable for …
accurate identification of ERBB2-amplified metastatic colorectal cancer patients suitable for …
Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer
…, T Xu, A Cardona, T Ruf, J Noe… - … England Journal of …, 2024 - Mass Medical Soc
Background Platinum-based chemotherapy is the recommended adjuvant treatment for patients
with resectable, ALK-positive non–small-cell lung cancer (NSCLC). Data on the efficacy …
with resectable, ALK-positive non–small-cell lung cancer (NSCLC). Data on the efficacy …
Identification of a phospholipase C β subtype in rat taste cells
P Rössler, C Kroner, J Freitag, J Noè, H Breer - European journal of cell …, 1998 - Elsevier
From rat circumvallate papillae a novel phospholipase C (PLC) subtype has been cloned
and identified as most closely related to human PLC β 2 . The corresponding mRNA was only …
and identified as most closely related to human PLC β 2 . The corresponding mRNA was only …
Diverse functional properties of Wilson disease ATP7B variants
…, A Kühne, A Bhattacharjee, L Raines, V Jantsch, J Noe… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Wilson disease is a severe disorder of copper metabolism caused
by mutations in ATP7B, which encodes a copper-transporting adenosine triphosphatase. …
by mutations in ATP7B, which encodes a copper-transporting adenosine triphosphatase. …
Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
J Noe, GA Kullak-Ublick, W Jochum, B Stieger… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11)
causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as …
causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as …