▪ Abstract Vitamin D is a secosteroid that is metabolically activated and degraded through the
actions of three cytochrome P450 hydroxylase enzymes. Bioactivation occurs through the …

Pseudovitamin D‐deficiency rickets (PDDR) is an autosomal recessive disorder that may be
due to impaired activity of 25‐hydroxyvitamin D‐1α‐hydroxylase, a renal cytochrome P450 …

The vitamin D status in a group of healthy free-living elderly people was determined by
measuring dietary and supplemental viatmin D intakes and the plasma concentration of 25-…

The subcellular distribution and properties of an enzyme system responsible for hydroxylation
of 25-hydroxycholecalciferol (25-OHD 3 ) to 1,25-dihydroxycholecalciferol (1,25-(OH) 2 D …

The current study investigated the action of 1,25-dihydroxyvitamin D 3 (1,25D) at the
genomic and signal transduction levels to induce rat cytochrome P450C24 (CYP24) gene …

A double-blind study was done giving 10 mg of copper/day as copper gluconate or placebo
capsules for 12 wk. The seven subjects receiving copper gluconate had no change in the …

Transcription of the CYP24 gene is induced by 1,25-(OH) 2 D 3 through a vitamin D receptor-dependent
process. The functional activities of three possible vitamin D response elements …

Inhibition of calcium absorption by dietary strontium is the result of a block in the renal
synthesis of 1,25-dihydroxycholecalciferol (1,25-(OH) 2 CC) from 25-hydroxycholecalciferol (25-…

Transcription of the rat CYP24 gene is induced by 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D
3 ) through two vitamin D response elements (VDREs). A functional Ras-dependent Ets-…

We previously demonstrated augmented endothelium-derived nitric oxide (EDNO)-dependent
pulmonary arterial dilation and increased arterial endothelial nitric oxide synthase (eNOS) …