In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system
…, RE Davidson, RJ Mireles, JS Janiszewski… - Drug Metabolism and …, 2008 - ASPET
Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one active
metabolite, and seven non-CNS-active compounds were tested in three P-glycoprotein (P…
metabolite, and seven non-CNS-active compounds were tested in three P-glycoprotein (P…
High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models
…, JS Janiszewski, K Jenkins, S Krueger… - Current drug …, 2008 - ingentaconnect.com
Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important
role in drug discovery and development and several reliable in vitro ADME models are …
role in drug discovery and development and several reliable in vitro ADME models are …
Using differential mobility spectrometry to measure ion solvation: an examination of the roles of solvents and ionic structures in separating quinoline-based drugs
C Liu, JCY Le Blanc, J Shields, JS Janiszewski… - Analyst, 2015 - pubs.rsc.org
Understanding the mechanisms and energetics of ion solvation is critical in many scientific
areas. Here, we present a methodlogy for studying ion solvation using differential mobility …
areas. Here, we present a methodlogy for studying ion solvation using differential mobility …
A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening
JS Janiszewski, KJ Rogers, KM Whalen… - Analytical …, 2001 - ACS Publications
HPLC/MS is a linear technique characterized by serial injection and analysis of individual
samples. Parallel-format high-throughput screens for druglike properties present a significant …
samples. Parallel-format high-throughput screens for druglike properties present a significant …
[HTML][HTML] Determining molecular properties with differential mobility spectrometry and machine learning
…, J Montgomery, GH Goetz, JS Janiszewski… - Nature …, 2018 - nature.com
The fast and accurate determination of molecular properties is highly desirable for many
facets of chemical research, particularly in drug discovery where pre-clinical assays play an …
facets of chemical research, particularly in drug discovery where pre-clinical assays play an …
Assessing physicochemical properties of drug molecules via microsolvation measurements with differential mobility spectrometry
The microsolvated state of a molecule, represented by its interactions with only a small number
of solvent molecules, can play a key role in determining the observable bulk properties of …
of solvent molecules, can play a key role in determining the observable bulk properties of …
AutoScan: an automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry
…, KJ Rogers, MJ Cole, JS Janiszewski - … in Mass Spectrometry, 2000 - Wiley Online Library
An automated flow injection analysis (FIA) mass spectrometry system (AutoScan) was
developed to allow rapid unattended determination of optimal conditions during mass (ms) and …
developed to allow rapid unattended determination of optimal conditions during mass (ms) and …
Development and validation of a high-sensitivity assay for an antipsychotic agent, CP-88,059, with solid-phase extraction and narrow-bore high-performance liquid …
JS Janiszewski, HG Fouda, RO Cole - Journal of Chromatography B …, 1995 - Elsevier
An analytical method has been developed and validated for the quantitation of CP-88,059
in human serum. The compound and internal standard were extracted from serum by solid-…
in human serum. The compound and internal standard were extracted from serum by solid-…
Perspectives on bioanalytical mass spectrometry and automation in drug discovery
JS Janiszewski, TE Liston, MJ Cole - Current drug metabolism, 2008 - ingentaconnect.com
The use of high speed synthesis technologies has resulted in a steady increase in the
number of new chemical entities active in the drug discovery research stream. Large …
number of new chemical entities active in the drug discovery research stream. Large …
[HTML][HTML] Discovery of compounds that positively modulate the high affinity choline transporter
…, SE Johnston, Y Maruyama, JS Janiszewski… - Frontiers in Molecular …, 2017 - frontiersin.org
Cholinergic hypofunction is associated with decreased attention and cognitive deficits in the
central nervous system in addition to compromised motor function. Consequently, …
central nervous system in addition to compromised motor function. Consequently, …