Diethylamine has been treated with aluminum chloride and tetrafluoroethylene at 90 to
obtain an unidentified liquid boiling at 176-177 and 761 mm. 3 Rigby and Schroe-der4 have …

GDC-0834, a Bruton’s tyrosine kinase inhibitor investigated as a potential treatment of
rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis …

Using S-adenosyl-methionine as the methyl donor, caffeic acid O-methyltransferase from
sorghum (Sorghum bicolor; SbCOMT) methylates the 5-hydroxyl group of its preferred substrate…

During the course of our research efforts to understand the kinetics of human aldehyde oxidase
as a xenobiotic-clearing enzyme, we investigated the effect of eight different inhibitors on …

The goal of this study was to provide a reasonable assessment of how probe substrate
selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, …

Aldehyde oxidase (AOX) is a cytosolic enzyme expressed across a wide range of species,
including guinea pig and rhesus monkey. These species are believed to be the best …

The function of the enzyme human aldehyde oxidase (AOX1) is uncertain; however, recent
studies have implicated significant biochemical involvement in humans. AOX1 has also …

Drug discovery programs routinely perform pharmacokinetic (PK) studies in mice to
prioritize lead compounds based on anticipated exposure-efficacy and exposure-toxicity …

When investigating the potential for xanthine oxidase (XO)-mediated metabolism of a new
chemical entity in vitro, selective chemical inhibition experiments are typically used. Most …

The mechanistic understanding of interactions between diet-derived substances and
conventional medications in humans is nascent. Most investigations have examined cytochrome …