Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity
…, M Box, P Johnström, K Varnäs, J Malmquist… - Clinical Cancer …, 2016 - AACR
Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC)
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …
Preclinical comparison of the blood–brain barrier permeability of osimertinib with other EGFR TKIs
…, R Arakawa, M Kondrashov, J Malmquist… - Clinical Cancer …, 2021 - AACR
Purpose: Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of
both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–…
both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–…
Chemistry and biology of some low molecular weight boron compounds for boron neutron capture therapy
…, L Gedda, T Hartman, J Malmquist… - Journal of neuro …, 1997 - Springer
Boronated DNA targeting agents are especially attractive candidatesfor BNCT because they
may deliver boron-10 tothe nuclei of tumor cells. Numerous boron-containing analogshave …
may deliver boron-10 tothe nuclei of tumor cells. Numerous boron-containing analogshave …
First Radiolabeling of a Ganglioside with a Positron Emitting Radionuclide: In Vivo PET Demonstrates Low Exposure of Radiofluorinated GM1 in Non-human Primate …
…, P Johnström, R Arakawa, J Malmquist… - ACS Chemical …, 2020 - ACS Publications
Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An
important member of the ganglioside family is the monosialylganglioside GM1, which has …
important member of the ganglioside family is the monosialylganglioside GM1, which has …
Asymmetric synthesis of p-carboranylalanine (p-Car) and 2-methyl-o-carboranylalanine (Me-o-Car).
J Malmquist, S Sjöberg - Tetrahedron, 1996 - Elsevier
Two new α-amino acids containing the 1, 2-and the 1, 12-dicarba-closo-dodecaborane (12)
cages, namely p-carboranylalanine (1), and 2-methyl-o-carboranylalanine (2), were …
cages, namely p-carboranylalanine (1), and 2-methyl-o-carboranylalanine (2), were …
Synthesis of para-and nido-carboranyl phenanthridinium compounds for neutron capture therapy
…, H Ghaneolhosseini, CLA Henssen, J Malmquist… - Tetrahedron letters, 1996 - Elsevier
The syntheses of two novel para-carboranyl and two novel nido-carboranyl
phenanthridinium compounds as potential boron delivery agents for Neutron Capture …
phenanthridinium compounds as potential boron delivery agents for Neutron Capture …
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing
P Johnström, L Bergman, K Varnäs, J Malmquist… - Nuclear Medicine and …, 2015 - Elsevier
… transformation of [ 14 C]potassium cyanide to benzoyl [ 14 C]isothiocyanate via [ 14 C]potassium
thiocyanate and the scope for optimizing reaction times in subsequent steps (Malmquist…
thiocyanate and the scope for optimizing reaction times in subsequent steps (Malmquist…
Synthesis of. omega.-(aminoalkyl)-1, 2-closo-dicarbadodecaboranes (12)
J Malmquist, S Sjoeberg - Inorganic Chemistry, 1992 - ACS Publications
Conclusion We have synthesized chloryl chloride for the first time according to four different
routes. This novel chlorine oxide is of sufficient (58)(a) Vaida, V.; Solomon, S.; Richard, EC; …
routes. This novel chlorine oxide is of sufficient (58)(a) Vaida, V.; Solomon, S.; Richard, EC; …
Synthesis and radioiodination of 7‐(3′‐ammoniopropyl)‐7,8‐dicarba‐nido‐undecaborate(‐1), (ANC)
S Ghirmai, J Malmquist, H Lundquist… - Journal of Labelled …, 2004 - Wiley Online Library
Derivatives of nido‐carborate have potential use in tumour targeting as hydrophilic boron‐rich
compounds for boron neutron capture therapy (BNCT) and as pendant groups for …
compounds for boron neutron capture therapy (BNCT) and as pendant groups for …
D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]‐MNPA, [3H]‐(+)‐PHNO, and [3H]‐raclopride
…, J Zysk, P Dorff, CS Elmore, P Ström, J Malmquist… - Synapse, 2010 - Wiley Online Library
Positron emission tomography (PET) antagonist ligands such as [ 11 C]‐raclopride are
commonly used to study dopamine D2 receptor (D2) binding of antipsychotics. It has been …
commonly used to study dopamine D2 receptor (D2) binding of antipsychotics. It has been …