[HTML][HTML] The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family

F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically, …

Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides

…, P Coelho, J Gaspar, M Alves, B Laffon, J Rueff… - …, 2006 - academic.oup.com
Widespread use of pesticides in agriculture represents a threat not only to the environment
but also to human populations exposed to them. Many of these compounds are capable of …

[HTML][HTML] mRNA therapy at the convergence of genetics and nanomedicine

J Conde, R Langer, J Rueff - Nature Nanotechnology, 2023 - nature.com
Since the early 1990s, the intersection of genetics and nanomedicine has found a home in
the clinic as one of the game changers of the past decade, holding great promise in fighting …

Cancer drug resistance: A brief overview from a genetic viewpoint

J Rueff, AS Rodrigues - Cancer Drug Resistance: Overviews and Methods, 2016 - Springer
Cancer drug resistance leading to therapeutic failure in the treatment of many cancers
encompasses various mechanisms and may be intrinsic relying on the patient’s genetic makeup …

Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51

…, AP Azevedo, V Teixeira, JE Pina, J Rueff… - Cancer …, 2010 - Elsevier
The possible role for DNA repair deficiencies in cancer development, namely in breast cancer
has been the subject of increasing interest since it has been reported that breast cancer …

Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1

…, AR Fernandes, P Tavares, A Laires, J Rueff… - Leukemia & …, 2011 - Taylor & Francis
About 20% of patients with chronic myeloid leukemia (CML) do not respond to treatment with
imatinib either initially or because of acquired resistance. To study the development of CML …

Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochore-containing …

H Caria, T Chaveca, A Laires, J Rueff - Mutation Research/Genetic …, 1995 - Elsevier
Quercetin, a mutagenic flavonoid widely distributed in edible plants, was studied for the
induction of micronuclei (MN). We have carried out the MN assay in bone marrow polychromatic …

Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts

…, MI Churchwell, DR Doerge, J Rueff… - Toxicological …, 2007 - academic.oup.com
Acrylamide (AA) is a suspected human carcinogen generated in carbohydrate-rich
foodstuffs upon heating. Glycidamide (GA), formed via epoxidation, presumably mediated by …

Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria

J Calado, K Soto, C Clemente, P Correia, J Rueff - Human genetics, 2004 - Springer
Familial renal glucosuria is an inherited renal tubular disorder. A homozygous nonsense
mutation in the SLC5A2 gene, encoding the sodium/glucose co-transporter SGLT2, has …

Genetic effects and biotoxicity monitoring of occupational styrene exposure

J Rueff, JP Teixeira, LS Santos, JF Gaspar - Clinica chimica acta, 2009 - Elsevier
Styrene is a commercially important chemical widely used in the manufacture of synthetic
rubber, resins, polyesters, and plastics. The highest levels of human exposure to styrene …