Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms.
Leptin is synthesized by perivascular adipose tissue (PVAT). The hypothesis of this study …

BACKGROUND Tissue factor (TF) is an evolutionary conserved glycoprotein that plays an
important role in the pathogenesis of cancer. TF is expressed in 2 naturally occurring protein …

Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary
to ensure that the prescribing competency of future doctors is of a uniform high standard. …

Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of
hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from …

Introduction Multimorbidity in advanced age and the need for drug treatment may lead to
polypharmacy, while pharmacokinetic and pharmacodynamic changes may increase the risk of …

Background: Glomerular hyperfiltration (GH) is an important mechanism in the development
of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and …

Background Glaucoma comprises age-related neurodegenerative diseases of retinal
ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the …

Interindividual variability in the drug-metabolizing activity of the CYP3A5 enzyme is mainly
due to a single nucleotide polymorphism in CYP3A5, leading to low expression in …

Extracellular matrix expansion in the glomerular mesangium contributes to the development
of glomerulosclerosis and chronic renal disease in arterial hypertension. Transforming …

The influence of CYP2D6 genotype on the efficacy of tamoxifen (Tam) has been extensively
analyzed in early breast cancer with conflicting results. However, there is only scarce data …