Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
…, K Sai, Y Ohno, Y Saito, J Sawada - Drug metabolism and …, 2004 - jstage.jst.go.jp
… and Sawada, J.: CYP3A4 gene polymorphism in uence … and Sawada, J. Appar ent low
frequency of sequence variability within … and Sawada, J.: Single nucleotide poly morphisms and …
frequency of sequence variability within … and Sawada, J.: Single nucleotide poly morphisms and …
[HTML][HTML] The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
R Groisman, J Polanowska, I Kuraoka, J Sawada… - Cell, 2003 - cell.com
Nucleotide excision repair (NER) is a major cellular defense against the carcinogenic effects
of ultraviolet light from the sun. Mutational inactivation of NER proteins, like DDB and CSA, …
of ultraviolet light from the sun. Mutational inactivation of NER proteins, like DDB and CSA, …
Coordinated histone modifications mediated by a CtBP co-repressor complex
The transcriptional co-repressor CtBP (C-terminal binding protein) is implicated in tumorigenesis
because it is targeted by the adenovirus E1A protein during oncogenic transformation 1…
because it is targeted by the adenovirus E1A protein during oncogenic transformation 1…
HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis
…, K Matsunaga, M Tohkin, K Kurose, J Sawada… - 2008 - Future Medicine
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of …
rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of …
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1* 6 and* 28
…, S Ozawa, K Suzuki, N Kaniwa, J Sawada… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …
Functional analysis of SNPs variants of BCRP/ABCG2
C Kondo, H Suzuki, M Itoda, S Ozawa, J Sawada… - Pharmaceutical …, 2004 - Springer
Purpose. The aim of the current study was to identify the effect of single nucleotide
polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, …
polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, …
UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecan‐administered Japanese Patients with Cancer
…, R Hasegawa, N Kaniwa, J Sawada… - Clinical …, 2004 - Wiley Online Library
Purpose A comprehensive haplotype analysis of UGT1A1 in the Japanese population was
conducted, and the effects of these haplotypes were investigated with respect to UGT1A1‐…
conducted, and the effects of these haplotypes were investigated with respect to UGT1A1‐…
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population
…, Y Kitamura, N Kamatani, S Ozawa, J Sawada - Human …, 2004 - Wiley Online Library
In order to identify single nucleotide polymorphisms (SNPs) and haplotype frequencies of
CYP3A4 in a Japanese population, the distal enhancer and proximal promoter regions, all …
CYP3A4 in a Japanese population, the distal enhancer and proximal promoter regions, all …
Comparative study of in vitro digestibility of food proteins and effect of preheating on the digestion
…, R Teshima, H Okunuki, J Sawada - Biological and …, 2003 - jstage.jst.go.jp
MATERIALS AND METHODS Materials Pepsin (catalog number P6887), pancreatin (catalog
number P8096), and the test proteins were purchased from Sigma Chemical Co.(St. Louis, …
number P8096), and the test proteins were purchased from Sigma Chemical Co.(St. Louis, …
Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African …
…, T Tanaka-Kagawa, Y Saito, M Saeki, J Sawada… - Drug Metabolism and …, 2005 - ASPET
Ethnic differences in genetic polymorphisms in UDP-glucuronosyltransferase 1A1 (UGT1A1)
were investigated among African-Americans, Caucasians, and Japanese using samples …
were investigated among African-Americans, Caucasians, and Japanese using samples …