Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights
M Hashizume, SL Tan, J Takano… - International reviews …, 2015 - Taylor & Francis
Pro-inflammatory cytokines play a major role in the initiation and maintenance of joint
inflammation and destruction in rheumatoid arthritis (RA). The therapeutic success of biologics …
inflammation and destruction in rheumatoid arthritis (RA). The therapeutic success of biologics …
Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein
T Tachibana, M Kato, J Takano… - Current drug …, 2010 - ingentaconnect.com
Recently, interest has grown in drug-drug interactions (DDIs) involving the inhibition of
intestinal CYP3A4, P-glycoprotein (P-gp), and other drug efflux transporters. The criteria for …
intestinal CYP3A4, P-glycoprotein (P-gp), and other drug efflux transporters. The criteria for …
The prediction of the relative importance of CYP3A/P-glycoprotein to the nonlinear intestinal absorption of drugs by advanced compartmental absorption and transit …
J Takano, K Maeda, MB Bolger, Y Sugiyama - Drug Metabolism and …, 2016 - ASPET
Intestinal CYP3A and P-glycoprotein (P-gp) decrease the intestinal absorption of substrate
drugs. Since substrate specificity of CYP3A often overlaps that of P-gp, and estimation of their …
drugs. Since substrate specificity of CYP3A often overlaps that of P-gp, and estimation of their …
Thermophysical properties of liquid Co measured by electromagnetic levitation technique in a static magnetic field
M Watanabe, J Takano, M Adachi, M Uchikoshi… - The Journal of Chemical …, 2018 - Elsevier
Density, normal spectral emissivity, heat capacity, and thermal conductivity of liquid Co
were measured by an electromagnetic levitation technique in a static magnetic field. High-purity …
were measured by an electromagnetic levitation technique in a static magnetic field. High-purity …
Cryopreservation of in vitro-grown apical shoot tips of strawberry by vitrification
T Niino, D Tanaka, S Ichikawa, J TAKANO… - Plant …, 2003 - jstage.jst.go.jp
After the strawberry shoots on culture medium were coldhardened at 5'C for 203_ Odays, shoot
tips were dissected and precultured at 5'C for Iday on MS medium containing 2M glycerol …
tips were dissected and precultured at 5'C for Iday on MS medium containing 2M glycerol …
Organic anion transporting polypeptide 1a4 is responsible for the hepatic uptake of cardiac glycosides in mice
J Takano, K Maeda, H Kusuhara, Y Sugiyama - Drug Metabolism and …, 2018 - ASPET
Among organic anion transporting polypeptide (Oatp) family transporters expressed in the
rodent liver, such as Oatp1a1, Oatp1a4, Oatp1b2, and Oatp2b1, Oatp1a4 has a unique …
rodent liver, such as Oatp1a1, Oatp1a4, Oatp1b2, and Oatp2b1, Oatp1a4 has a unique …
Development of pH-independent drug release formulation using Lipocalin-type prostaglandin D synthase
M Mizoguchi, M Nakatsuji, J Takano, O Ishibashi… - Journal of …, 2016 - Elsevier
The purpose of this study was to develop a pH-independent drug release formulation using
lipocalin-type prostaglandin D synthase, a member of the lipocalin superfamily, with the …
lipocalin-type prostaglandin D synthase, a member of the lipocalin superfamily, with the …
Aggregation of star-shaped tris (tetrathiafulvalenylethynyl) benzene in solution and in the solid state
M Hasegawa, J Takano, H Enozawa, Y Kuwatani… - Tetrahedron letters, 2004 - Elsevier
Neutral hexabutylthio-1,3,5-tris(tetrathiafulvalenylethynyl)benzene aggregates in CD 3 CN–CDCl
3 and CDCl 3 , whereas stronger stacking of the cationic counterparts in solution has …
3 and CDCl 3 , whereas stronger stacking of the cationic counterparts in solution has …
Importance of free water in controlling granule and tablet properties in a novel granulation method, green fluidized bed granulation (GFBG)
…, Y Matsuura, N Ohyagi, M Mizoguchi, J Takano… - International Journal of …, 2019 - Elsevier
In the pharmaceutical field, green fluidized bed granulation (GFBG) is a novel and eco-friendly
manufacturing technology used to produce desired granules via simple blending and …
manufacturing technology used to produce desired granules via simple blending and …
Intramolecular charge interaction in the radical cations and dications of conjugated tetrathiafulvalene dimers
M Iyoda, M Hasegawa, J Takano, K Hara… - Chemistry …, 2002 - academic.oup.com
Dimeric TTFs have been synthesized by using palladium-catalyzed reactions. Although TTFs
are very sensitive under oxidation conditions, the palladium-catalyzed reactions can be …
are very sensitive under oxidation conditions, the palladium-catalyzed reactions can be …