Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme
…, I Ulmanen, K Melen, I Julkunen, J Taskinen - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received January 11, 1995® abstract: Human soluble (S) and
membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1. 1.6) enzymes have been …
membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1. 1.6) enzymes have been …
Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic …
…, N Kalkkinen, I Ulmanen, E Nissinen, J Taskinen - Journal of Biological …, 1994 - ASBMB
The binding of a new calcium sensitizer, levosimendan, to human cardiac troponin C (cTnC)
is described. Fluorescence studies done on dansylated recombinant human cTnC and a site…
is described. Fluorescence studies done on dansylated recombinant human cTnC and a site…
Prediction of physicochemical properties based on neural network modelling
J Taskinen, J Yliruusi - Advanced drug delivery reviews, 2003 - Elsevier
The literature describing neural network modelling to predict physicochemical properties of
organic compounds from the molecular structure is reviewed from the perspective of …
organic compounds from the molecular structure is reviewed from the perspective of …
Aqueous solubility prediction of drugs based on molecular topology and neural network modeling
J Huuskonen, M Salo, J Taskinen - Journal of chemical information …, 1998 - ACS Publications
A method for predicting the aqueous solubility of drug compounds was developed based on
topological indices and artificial neural network (ANN) modeling. The aqueous solubility …
topological indices and artificial neural network (ANN) modeling. The aqueous solubility …
[HTML][HTML] X-ray crystal structure of human dopamine sulfotransferase, SULT1A3: molecular modeling and quantitative structure-activity relationship analysis …
…, AM Hood, S Modi, A Hersey, J Taskinen… - Journal of Biological …, 1999 - ASBMB
Humans are one of the few species that produce large amounts of catecholamine sulfates,
and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to catalyze the …
and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to catalyze the …
[HTML][HTML] Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs): UGT1A9 is more resistant to detergent inhibition than the …
…, L Luukkanen, S Mörsky, J Taskinen… - Journal of Biological …, 2003 - ASBMB
Eight human liver UDP-glucuronosyltransferases (UGTs) were expressed in baculovirus-infected
insect cells as fusion proteins carrying a short C-terminal extension that ends with 6 …
insect cells as fusion proteins carrying a short C-terminal extension that ends with 6 …
Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs
T Salminen, A Pulli, J Taskinen - Journal of pharmaceutical and biomedical …, 1997 - Elsevier
Retention factors were determined for a set of 26 drugs, for which brain/blood concentration
data are available, using immobilised artificial membrane (IAM) chromatography. The …
data are available, using immobilised artificial membrane (IAM) chromatography. The …
Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase
P Lautala, I Ulmanen, J Taskinen - Molecular pharmacology, 2001 - ASPET
Molecular mechanisms determining the turn-over rate and specificity of catechol O-methylation
were studied by combining enzyme kinetic measurements, computational modeling of …
were studied by combining enzyme kinetic measurements, computational modeling of …
Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamine …
…, J Magdalou, L Luukkanen, J Taskinen… - Analytical …, 2002 - ACS Publications
The applicability of different ionization techniques, electrospray ionization (ESI), atmospheric
pressure chemical ionization (APCI), and a novel atmospheric pressure photoionization (…
pressure chemical ionization (APCI), and a novel atmospheric pressure photoionization (…
Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.
T Wikberg, A Vuorela, P Ottoila, J Taskinen - Drug Metabolism and …, 1993 - ASPET
Metabolites of entacapone [(E)-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide++
+], a potent inhibitor of catechol-O-methyltransferase, were isolated from human and …
+], a potent inhibitor of catechol-O-methyltransferase, were isolated from human and …