A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases
in accordance with the international rules for gene nomenclature. The root symbol (…

Classification of humans as rapid or slow acetylators is based on hereditary differences in
rates of N-acetylation of therapeutic and carcinogenic agents, but N-acetylation of certain …

… Vatsis, Cynthia F. Bartels, Bert N. La Du, and Oksana Lockridge* …

The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences
in N-acetyltransferase (NAT) activity with therapeutic agents (rapid and slow acetylation)…

Intramolecular and intermolecular kinetic isotope effects (KIEs) were determined for
hydroxylation of the enantiomers of trans-2-(p-trifluoromethylphenyl)cyclopropylmethane (1) by …

The function of the unique axial thiolate ligand of cytochrome P450 has been investigated
by mutagenesis of the active-site cysteine with other amino acids in NH 2 -truncated P450s …

Evidence for multiple functional active oxidants in cytochrome P450-catalyzed reactions was
previously obtained in this laboratory with mutants in which proton delivery was perturbed …

… Acetylated 4-aminosalicylate was synthesized by one of us (KP Vatsis) with the help of Dr.
Alfin DN Vaz of the Department of Biological Chemistry at this institution, and the purity of the …

The hydroxylation of prostaglandin (PG) E1, PGE2, and PGA1 was investigated in a reconstituted
rabbit liver microsomal enzyme system containing phenobarbital-inducible isozyme 2 …

Individual variability in p-aminobenzoic acid N-acetylation... : Pharmacogenetics and
Genomics Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase …