… secretion results in reduced intestinal metabolite formation, as confirmed in a recent
theoretical examination of TM and SFM (unpublished data of KS Pang, E. Tseng, and D. Tam). …

This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems. …

Two commonly used models of hepatic drug clearance are examined. The “well-stirred”
model (model I) views the liver as a well-stirred compartment with concentration of drug in the …

Advances in nanotechnology research on quantum dots (QDs)—water soluble ZnS‐capped,
CdSe fluorescent semiconductor nanocrystals—for in vivo biomedical applications have …

Theoretical analysis of two models of hepatic drug clearance revealed that one powerful
discriminator between them is the effect of changes of hepatic blood flow on either the emergent …

Background: The Caco-2 monolayer has been used extensively for the high-throughput
screening of drug permeability and identification of substrates, inhibitors, and inducers of …

We demonstrate a role of the vitamin D receptor (VDR) in reducing cerebral soluble and
insoluble amyloid-β (Aβ) peptides. Short-term treatment of two human amyloid precursor protein-…

We explored the properties of a catenary model that includes the basolateral (B), apical (A),
and cellular compartments via simulations under linear and nonlinear conditions to …

… Drs Gil Berglund, Atkinson, Sugiyama, and Pang took sabbaticals from the FDA at
different times between 2008 and 2011. … Sandy Pang PhD … Sandy Pang PhD …

Effective combination chemotherapy requires the delivery of drugs of synergism to tumor
sites while sparing normal tissues. Herein we investigated whether coencapsulation of …