… mg/kg doses and >20 µM in dogs following a 30 mg/kg oral dose. (C) (+)-SJ733 exhibits no
significant toxicology at doses up to 200 mg/kg in … tolerated dose >240 mg/kg from 7-d repeat …

… DMN failed to induce mutations in 6 week old mice at 2 mg/kg/day, but 4 mg/kg/day yielded
significant elevations in hepatic mutations. Sequencing results indicate that treatment of mice …

… Animals were administered lamivudine via oral gavage at a dose of 60 mg/kg and a volume
of 6 ml/kg body weight. Blood (~300 μl; processed to ~120 μl of plasma) was collected from …

… Mice were euthanized by administration of 60 mg/kg sodium pentobarbital. For mutation
analysis, spleens were removed, quick-frozen in liquid nitrogen, and stored at -80C until DNA …

The increasing use of nucleic acid-based therapeutics has created a need for new methods
of determining tissue distribution and levels. Radiolabel methods may not always be …

… kg (intravenously) or 30 mg/kg (orally). The human equivalent dose of amiodarone in guinea
pigs was determined to be 160 mg/kg … those in human serum (27 mg/kg dose; C max = 4.4–…

… On the other hand, 7- and 14-day dose-ranging toxicology and toxicokinetic studies of 2 do
not show these toxicological characteristics (CE Green, KG O'Loughlin, J. Marquis, RP Iyer, …

… Doses were administered at 15 mg/kg for IV and 10–200 mg/kg for PO with 20 mice in each
dosage group. Two samples were taken from each mouse, with the first sample being a retro-…

… a pre-grazing herbage mass of 1,492 kg of DM/ha. The TMR offered … kg of DM), concentrate
blend (8.6 kg of DM), grass silage (3.5 kg of DM), molasses (0.7 kg of DM), and straw (0.5 kg …

… Mean herbage mass throughout the measurement periods was 1,075 kg of DM/ha and
1,993 kg of DM/ha for the LHM and HHM treatments, respectively. Grass quality in terms of …